CT and Multimodal MR Imaging Features of Embryonal Tumors with Multilayered Rosettes in Children.
Journal
AJNR. American journal of neuroradiology
ISSN: 1936-959X
Titre abrégé: AJNR Am J Neuroradiol
Pays: United States
ID NLM: 8003708
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
24
10
2018
accepted:
28
01
2019
pubmed:
9
3
2019
medline:
17
3
2020
entrez:
9
3
2019
Statut:
ppublish
Résumé
Embryonal tumors with multilayered rosettes, C19MC-altered, are brain tumors occurring in young children, which were clearly defined in the 2016 World Health Organization classification of central nervous system neoplasms. Our objective was to describe the multimodal imaging characteristics of this new entity. We performed a retrospective monocentric review of embryonal brain tumors and looked for embryonal tumors with multilayered rosettes with confirmed C19MC alteration. We gathered morphologic imaging data, as well as DWI and PWI data (using arterial spin-labeling and DSC). We included 16 patients with a median age of 2 years 8 months. Tumors were both supratentorial (56%, 9/16) and infratentorial (44%, 7/16). Tumors were large (median diameter, 59 mm; interquartile range, 48-71 mm), with absent (75%, 12/16) or minimal (25%, 4/16) peritumoral edema. Enhancement was absent (20%, 3/15) or weak (73%, 11/15), whereas intratumoral macrovessels were frequently seen (94%, 15/16) and calcifications were present in 67% (10/15). Diffusion was always restricted, with a minimal ADC of 520 mm Embryonal tumors with multilayered rosettes, C19MC-altered, have characteristic imaging features that could help in the diagnosis of this rare tumor in young children.
Sections du résumé
BACKGROUND AND PURPOSE
Embryonal tumors with multilayered rosettes, C19MC-altered, are brain tumors occurring in young children, which were clearly defined in the 2016 World Health Organization classification of central nervous system neoplasms. Our objective was to describe the multimodal imaging characteristics of this new entity.
MATERIALS AND METHODS
We performed a retrospective monocentric review of embryonal brain tumors and looked for embryonal tumors with multilayered rosettes with confirmed C19MC alteration. We gathered morphologic imaging data, as well as DWI and PWI data (using arterial spin-labeling and DSC).
RESULTS
We included 16 patients with a median age of 2 years 8 months. Tumors were both supratentorial (56%, 9/16) and infratentorial (44%, 7/16). Tumors were large (median diameter, 59 mm; interquartile range, 48-71 mm), with absent (75%, 12/16) or minimal (25%, 4/16) peritumoral edema. Enhancement was absent (20%, 3/15) or weak (73%, 11/15), whereas intratumoral macrovessels were frequently seen (94%, 15/16) and calcifications were present in 67% (10/15). Diffusion was always restricted, with a minimal ADC of 520 mm
CONCLUSIONS
Embryonal tumors with multilayered rosettes, C19MC-altered, have characteristic imaging features that could help in the diagnosis of this rare tumor in young children.
Identifiants
pubmed: 30846437
pii: ajnr.A6001
doi: 10.3174/ajnr.A6001
pmc: PMC7048518
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
732-736Informations de copyright
© 2019 by American Journal of Neuroradiology.
Références
AJR Am J Roentgenol. 2013 May;200(5):1115-24
pubmed: 23617498
Neuro Oncol. 2015 Aug;17(8):1157-65
pubmed: 25916887
Br J Radiol. 2016 Jun;89(1062):20150624
pubmed: 26975495
Childs Nerv Syst. 2013 May;29(5):849-54
pubmed: 23358909
Acta Neuropathol. 2010 Aug;120(2):253-60
pubmed: 20407781
J Neurooncol. 2007 Aug;84(1):91-8
pubmed: 17332950
Eur J Nucl Med Mol Imaging. 2017 Nov;44(12):2084-2093
pubmed: 28752225
Acta Neuropathol. 2011 Dec;122(6):783-5
pubmed: 22033877
Pediatr Neurosurg. 2015;50(1):42-7
pubmed: 25591930
Childs Nerv Syst. 2016 Feb;32(2):299-305
pubmed: 26438544
Virchows Arch. 2015 May;466(5):603-7
pubmed: 25697539
AJNR Am J Neuroradiol. 2014 Feb;35(2):395-401
pubmed: 23907239
Acta Neuropathol. 2011 Dec;122(6):787-90
pubmed: 22057788
Brain Pathol. 2014 Jan;24(1):45-51
pubmed: 23865520
Neurochirurgie. 2018 Aug 28;:
pubmed: 30170827
J Neurooncol. 2017 Dec;135(3):561-569
pubmed: 28856499
Pediatr Radiol. 2013 Mar;43(3):347-54
pubmed: 23143401
J Neuroimaging. 2018 Sep;28(5):483-489
pubmed: 29797626
Neuropathology. 2011 Dec;31(6):620-5
pubmed: 22103481
J Clin Pathol. 2014 Nov;67(11):1017-8
pubmed: 25194039
Radiology. 2016 Nov;281(2):553-566
pubmed: 27257950
Acta Neuropathol. 2014 Aug;128(2):279-89
pubmed: 24337497
Turk Neurosurg. 2019;29(3):451-454
pubmed: 28191622
Pathol Int. 2014 Sep;64(9):472-7
pubmed: 25186165
Neurosurg Focus. 2011 Jan;30(1):E2
pubmed: 21194275
Pediatr Blood Cancer. 2014 Jun;61(6):1132-4
pubmed: 24464920
Acta Neuropathol. 2014 Aug;128(2):291-303
pubmed: 24839957
Radiographics. 2018 Mar-Apr;38(2):525-541
pubmed: 29528832
J Neurosurg Pediatr. 2015 Sep;16(3):291-5
pubmed: 26090549
Childs Nerv Syst. 2010 Aug;26(8):1003-8
pubmed: 20499240
Zh Vopr Neirokhir Im N N Burdenko. 2011;75(4):25-33; discussion 33
pubmed: 22379850
Neuroradiology. 2018 Apr;60(4):437-446
pubmed: 29453753
AJNR Am J Neuroradiol. 2014 Oct;35(10):1996-2001
pubmed: 24948504
SAGE Open Med Case Rep. 2017 Dec 04;5:2050313X17745208
pubmed: 29230288
Acta Neuropathol. 2016 Jun;131(6):803-20
pubmed: 27157931