Kidney micro-organoids in suspension culture as a scalable source of human pluripotent stem cell-derived kidney cells.
Albumins
/ metabolism
Cell Culture Techniques
Cell Differentiation
Cells, Cultured
Doxorubicin
/ pharmacology
Gene Expression Regulation, Developmental
Humans
Kidney
/ cytology
Nephrons
/ metabolism
Organoids
Pluripotent Stem Cells
/ cytology
Signal Transduction
Transcription, Genetic
Wnt Proteins
/ metabolism
Kidney
Kidney micro-organoid
Nephron
Organoid
Pluripotent stem cell
Single cell profiling
Suspension culture
Journal
Development (Cambridge, England)
ISSN: 1477-9129
Titre abrégé: Development
Pays: England
ID NLM: 8701744
Informations de publication
Date de publication:
07 03 2019
07 03 2019
Historique:
received:
30
09
2018
accepted:
05
02
2019
entrez:
9
3
2019
pubmed:
9
3
2019
medline:
31
12
2019
Statut:
epublish
Résumé
Kidney organoids have potential uses in disease modelling, drug screening and regenerative medicine. However, novel cost-effective techniques are needed to enable scaled-up production of kidney cell types
Identifiants
pubmed: 30846463
pii: 146/5/dev172361
doi: 10.1242/dev.172361
pmc: PMC6432662
pii:
doi:
Substances chimiques
Albumins
0
Wnt Proteins
0
Doxorubicin
80168379AG
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIDDK NIH HHS
ID : UH3 DK107344
Pays : United States
Informations de copyright
© 2019. Published by The Company of Biologists Ltd.
Déclaration de conflit d'intérêts
Competing interestsM.H.L. and S.V.K. hold a patent for the described protocol.
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