Helicobacter suis infection alters glycosylation and decreases the pathogen growth inhibiting effect and binding avidity of gastric mucins.
Adult
Animals
Cell Proliferation
Chronic Disease
Female
Gastric Mucins
/ metabolism
Gastric Mucosa
/ microbiology
Gastritis
/ metabolism
Glycosylation
Helicobacter Infections
/ metabolism
Helicobacter heilmannii
/ physiology
Humans
Male
Middle Aged
Mucus
/ physiology
Protein Binding
Swine
Ulcer
/ metabolism
Journal
Mucosal immunology
ISSN: 1935-3456
Titre abrégé: Mucosal Immunol
Pays: United States
ID NLM: 101299742
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
27
09
2018
accepted:
10
02
2019
revised:
11
01
2019
pubmed:
9
3
2019
medline:
19
6
2019
entrez:
9
3
2019
Statut:
ppublish
Résumé
Helicobacter suis is the most prevalent non-Helicobacter pylori Helicobacter species in the human stomach and is associated with chronic gastritis, peptic ulcer disease, and gastric mucosa-associated lymphoid tissue (MALT) lymphoma. H. suis colonizes the gastric mucosa of 60-95% of pigs at slaughter age, and is associated with chronic gastritis, decreased weight gain, and ulcers. Here, we show that experimental H. suis infection changes the mucin composition and glycosylation, decreasing the amount of H. suis-binding glycan structures in the pig gastric mucus niche. Similarly, the H. suis-binding ability of mucins from H. pylori-infected humans is lower than that of noninfected individuals. Furthermore, the H. suis growth-inhibiting effect of mucins from both noninfected humans and pigs is replaced by a growth-enhancing effect by mucins from infected individuals/pigs. Thus, Helicobacter spp. infections impair the mucus barrier by decreasing the H. suis-binding ability of the mucins and by decreasing the antiprolific activity that mucins can have on H. suis. Inhibition of these mucus-based defenses creates a more stable and inhabitable niche for H. suis. This is likely of importance for long-term colonization and outcome of infection, and reversing these impairments may have therapeutic benefits.
Identifiants
pubmed: 30846831
doi: 10.1038/s41385-019-0154-4
pii: S1933-0219(22)00422-6
doi:
Substances chimiques
Gastric Mucins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
784-794Références
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