The Effects of Methylphenidate (Ritalin) on the Neurophysiology of the Monkey Caudal Prefrontal Cortex.

Animals Attention / drug effects Attention Deficit Disorder with Hyperactivity / drug therapy Central Nervous System Stimulants / pharmacology Dose-Response Relationship, Drug Electrodes, Implanted Macaca fascicularis Machine Learning Male Methylphenidate / pharmacology Neurons / drug effects Prefrontal Cortex / drug effects Signal Processing, Computer-Assisted Visual Perception / drug effects
Ritalin attention methylphenidate multielectrode array prefrontal cortex primates

Journal

eNeuro
ISSN: 2373-2822
Titre abrégé: eNeuro
Pays: United States
ID NLM: 101647362

Informations de publication

Date de publication:
Historique:
received: 23 09 2018
revised: 13 12 2018
accepted: 17 12 2018
entrez: 9 3 2019
pubmed: 9 3 2019
medline: 19 4 2019
Statut: epublish

Résumé

Methylphenidate (MPH), commonly known as Ritalin, is the most widely prescribed drug worldwide to treat patients with attention deficit disorders. Although MPH is thought to modulate catecholamine neurotransmission in the brain, it remains unclear how these neurochemical effects influence neuronal activity and lead to attentional enhancements. Studies in rodents overwhelmingly point to the lateral prefrontal cortex (LPFC) as a main site of action of MPH. To understand the mechanism of action of MPH in a primate brain, we recorded the responses of neuronal populations using chronic multielectrode arrays implanted in the caudal LPFC of two macaque monkeys while the animals performed an attention task (

Identifiants

DOI: 10.1523/ENEURO.0371-18.2018 PMID: 30847388 PMC: PMC6402537
pubmed: 30847388
doi: 10.1523/ENEURO.0371-18.2018
pii: eN-NWR-0371-18
pmc: PMC6402537
pii:
doi:

Substances chimiques

Central Nervous System Stimulants 0
Methylphenidate 207ZZ9QZ49

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : CIHR
ID : 501100000024
Pays : Canada

Références

Eur J Neurosci. 1999 Mar;11(3):1011-36
pubmed: 10103094
J Neurophysiol. 1999 May;81(5):2191-214
pubmed: 10322059
Nature. 1999 Jun 10;399(6736):575-9
pubmed: 10376597
Clin Pharmacokinet. 1999 Dec;37(6):457-70
pubmed: 10628897
J Neurosci. 2000 Mar 15;20(6):RC65
pubmed: 10704519
Rapid Commun Mass Spectrom. 2000;14(8):619-23
pubmed: 10786896
Annu Rev Neurosci. 2001;24:167-202
pubmed: 11283309
Psychopharmacology (Berl). 2003 Sep;169(2):150-60
pubmed: 12768267
Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):11041-6
pubmed: 12960378
J Neurophysiol. 2004 Jan;91(1):152-62
pubmed: 13679398
Nat Neurosci. 2004 May;7(5):446-51
pubmed: 15114356
Annu Rev Neurosci. 2004;27:611-47
pubmed: 15217345
Neuroimage. 2005 Apr 15;25(3):868-76
pubmed: 15808987
Cogn Affect Behav Neurosci. 2004 Dec;4(4):528-39
pubmed: 15849895
Behav Brain Funct. 2005 Apr 22;1(1):2
pubmed: 15916700
Philos Trans R Soc Lond B Biol Sci. 2005 Apr 29;360(1456):781-95
pubmed: 15937012
Biol Psychiatry. 2005 Jun 1;57(11):1410-5
pubmed: 15950015
Clin Psychol Rev. 2006 Aug;26(4):379-95
pubmed: 16504359
Nat Rev Neurosci. 2006 May;7(5):358-66
pubmed: 16760916
Biol Psychiatry. 2006 Nov 15;60(10):1111-20
pubmed: 16806100
J Comp Neurol. 2006 Sep 10;498(2):227-51
pubmed: 16856142
Science. 2007 Mar 30;315(5820):1860-2
pubmed: 17395832
Biol Psychiatry. 2008 Oct 1;64(7):626-35
pubmed: 18585681
Nat Rev Neurosci. 2009 Mar;10(3):173-85
pubmed: 19229240
J Comp Neurol. 1991 Aug 22;310(4):429-74
pubmed: 1939732
Science. 2009 May 29;324(5931):1207-10
pubmed: 19478185
Psychol Bull. 1992 Jul;112(1):155-9
pubmed: 19565683
Am J Psychiatry. 2009 Nov;166(11):1286-94
pubmed: 19755575
Neuron. 2009 Sep 24;63(6):879-88
pubmed: 19778515
Nat Neurosci. 2009 Dec;12(12):1594-600
pubmed: 19915566
J Neurosci. 2009 Dec 16;29(50):15621-9
pubmed: 20016076
Biol Psychiatry. 2010 Nov 1;68(9):854-60
pubmed: 20691429
J Am Acad Child Adolesc Psychiatry. 2010 Oct;49(10):1011-23
pubmed: 20855046
Neuroimage. 2011 Feb 14;54(4):3101-10
pubmed: 21029780
J Neurosci. 2010 Nov 24;30(47):15878-87
pubmed: 21106826
Neuron. 2011 Apr 14;70(1):141-52
pubmed: 21482363
Nature. 2011 May 15;474(7351):372-5
pubmed: 21572439
Science. 2011 Jun 24;332(6037):1568-71
pubmed: 21617042
Nat Neurosci. 2011 Jun 27;14(7):811-9
pubmed: 21709677
J Neurosci. 2011 Jul 20;31(29):10569-78
pubmed: 21775601
Biol Psychiatry. 2012 Mar 1;71(5):467-73
pubmed: 21890109
Pediatrics. 2011 Nov;128(5):1007-22
pubmed: 22003063
J Neurosci. 2011 Nov 30;31(48):17622-36
pubmed: 22131423
Neuron. 2011 Dec 22;72(6):1067-79
pubmed: 22196340
Biol Psychiatry. 2012 Aug 1;72(3):221-7
pubmed: 22209638
Neuron. 2012 Feb 9;73(3):581-94
pubmed: 22325208
J Cogn Neurosci. 2012 Jun;24(6):1371-81
pubmed: 22401288
Annu Rev Neurosci. 2012;35:73-89
pubmed: 22524787
Psychopharmacology (Berl). 2013 Aug;228(4):611-22
pubmed: 23529381
PLoS One. 2013 Apr 22;8(4):e61503
pubmed: 23630595
Nat Neurosci. 2013 Aug;16(8):1140-5
pubmed: 23792944
Annu Rev Neurosci. 2013 Jul 8;36:451-66
pubmed: 23841841
J Am Acad Child Adolesc Psychiatry. 2014 Jan;53(1):34-46.e2
pubmed: 24342384
Nat Neurosci. 2014 Apr;17(4):491-6
pubmed: 24671065
Nat Neurosci. 2014 Oct;17(10):1410-7
pubmed: 25195105
Biol Psychiatry. 2015 Jun 1;77(11):940-50
pubmed: 25499957
Neuron. 2015 Jan 7;85(1):202-215
pubmed: 25500502
J Cogn Neurosci. 2015 Jun;27(6):1069-89
pubmed: 25591060
J Neurosci. 2015 Jun 17;35(24):9038-49
pubmed: 26085629
Prog Neurobiol. 2015 Sep;132:59-80
pubmed: 26159708
Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):E6973-82
pubmed: 26621747
J Comp Neurol. 1989 Aug 15;286(3):353-75
pubmed: 2768563
Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):E7297-E7306
pubmed: 27807140
J Neurosci. 2017 Mar 1;37(9):2387-2394
pubmed: 28154152
Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):E2494-E2503
pubmed: 28275096
Trends Neurosci. 2017 Jun;40(6):328-346
pubmed: 28515011
Biol Psychiatry. 2017 Nov 1;82(9):687-694
pubmed: 28599833
Science. 1985 Aug 23;229(4715):782-4
pubmed: 4023713
J Pharmacol Exp Ther. 1983 Aug;226(2):382-6
pubmed: 6410043
Annu Rev Neurosci. 1995;18:193-222
pubmed: 7605061
Neuron. 1995 Mar;14(3):477-85
pubmed: 7695894
Arch Gen Psychiatry. 1995 Jun;52(6):456-63
pubmed: 7771915
J Neurosci. 1996 Feb 15;16(4):1486-510
pubmed: 8778300
Neuron. 1997 Aug;19(2):219-21
pubmed: 9292712
Cereb Cortex. 1998 Mar;8(2):164-72
pubmed: 9542895
Am J Psychiatry. 1998 Oct;155(10):1325-31
pubmed: 9766762

Auteurs

Sébastien Tremblay (S)

Montreal Neurological Institute, McGill University, Montreal, Québec, H3A 2B4, Canada.
ORCID: 0000-0001-6251-9797

Florian Pieper (F)

Institute for Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf 20251, Hamburg, Germany.

Adam Sachs (A)

Department of Surgery, The Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, K1H 8L6, Canada.

Ridha Joober (R)

Douglas Mental Health University Institute, McGill University, Montreal, Québec, H4H 1R3, Canada.
ORCID: 0000-0003-3492-807X

Julio Martinez-Trujillo (J)

Robarts Research Institute, Departments of Psychiatry, Physiology and Pharmacology.
Schulich School of Medicine and Dentistry, Brain and Mind Institute, University of Western Ontario, London, Ontario, N6A 5C1, Canada.

Articles similaires

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Meal Timing and Anthropometric and Metabolic Outcomes: A Systematic Review and Meta-Analysis.

Hiu Yee Liu, Ashley A Eso, Nathan Cook et al.
1.00
Humans Meals Time Factors Female Adult

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › The Effects of Methylphenidate (Ritalin) on...
questionsmedicales.fr › Phénomènes psychologiques › Attention › The Effects of Methylphenidate (Ritalin) on...
questionsmedicales.fr › Troubles mentaux › Troubles du développement neurologique › Troubles déficitaires de l'attention et du comportement perturbateur › Trouble déficitaire de l'attention avec hyperactivité › The Effects of Methylphenidate (Ritalin) on...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Stimulants du système nerveux central › The Effects of Methylphenidate (Ritalin) on...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › The Effects of Methylphenidate (Ritalin) on...
questionsmedicales.fr › Équipement et fournitures › Prothèses et implants › Électrodes implantées › The Effects of Methylphenidate (Ritalin) on...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca › Macaca fascicularis › The Effects of Methylphenidate (Ritalin) on...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Algorithmes › Intelligence artificielle › Apprentissage machine › The Effects of Methylphenidate (Ritalin) on...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pipéridines › Méthylphénidate › The Effects of Methylphenidate (Ritalin) on...
questionsmedicales.fr › Cellules › Neurones › The Effects of Methylphenidate (Ritalin) on...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Lobe frontal › Cortex préfrontal › The Effects of Methylphenidate (Ritalin) on...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Traitement du signal assisté par ordinateur › The Effects of Methylphenidate (Ritalin) on...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Perception › Perception visuelle › The Effects of Methylphenidate (Ritalin) on...