Bioactive Materials Facilitating Targeted Local Modulation of Inflammation.

CAD, coronary artery disease ELISA, enzyme-linked immunoadsorbent assay IL, interleukin PCL, polycaprolactone PIII, plasma immersion ion implantation TGF, transforming growth factor TNF, tumor necrosis factor covalent biomolecule immobilization inflammation interleukin-4 neointimal hyperplasia plasma-based ion implantation qPCR, quantitative polymerase chain reaction radical functionalized surface vascular graft

Journal

JACC. Basic to translational science
ISSN: 2452-302X
Titre abrégé: JACC Basic Transl Sci
Pays: United States
ID NLM: 101677259

Informations de publication

Date de publication:
Feb 2019
Historique:
received: 10 08 2018
revised: 10 10 2018
accepted: 12 10 2018
entrez: 9 3 2019
pubmed: 9 3 2019
medline: 9 3 2019
Statut: epublish

Résumé

Cardiovascular disease is an inflammatory disorder that may benefit from appropriate modulation of inflammation. Systemic treatments lower cardiac events but have serious adverse effects. Localized modulation of inflammation in current standard treatments such as bypass grafting may more effectively treat CAD. The present study investigated a bioactive vascular graft coated with the macrophage polarizing cytokine interleukin-4. These grafts repolarize macrophages to anti-inflammatory phenotypes, leading to modulation of the pro-inflammatory microenvironment and ultimately to a reduction of foreign body encapsulation and inhibition of neointimal hyperplasia development. These resulting functional improvements have significant implications for the next generation of synthetic vascular grafts.

Identifiants

DOI: 10.1016/j.jacbts.2018.10.004 PMID: 30847420 PMC: PMC6390730
pubmed: 30847420
doi: 10.1016/j.jacbts.2018.10.004
pii: S2452-302X(18)30272-9
pmc: PMC6390730
doi:

Types de publication

Journal Article

Langues

eng

Pagination

56-71

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Auteurs

Richard P Tan (RP)

Heart Research Institute, Sydney, New South Wales, Australia.
Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.

Alex H P Chan (AHP)

Heart Research Institute, Sydney, New South Wales, Australia.
Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.

Simon Wei (S)

Science and Engineering Faculty, Queensland University of Technology, Brisbane, Queensland, Australia.

Miguel Santos (M)

Heart Research Institute, Sydney, New South Wales, Australia.
School of Physics, University of Sydney, Sydney, New South Wales, Australia.

Bob S L Lee (BSL)

Heart Research Institute, Sydney, New South Wales, Australia.
Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.

Elysse C Filipe (EC)

Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.
Garvan Institute of Medical Research, Cancer Division, Sydney, New South Wales, Australia.

Behnam Akhavan (B)

Heart Research Institute, Sydney, New South Wales, Australia.
School of Physics, University of Sydney, Sydney, New South Wales, Australia.
School of Aerospace, Mechanical and Mechatronic Engineering, University of Sydney, Sydney, New South Wales, Australia.

Marcela M Bilek (MM)

School of Physics, University of Sydney, Sydney, New South Wales, Australia.
School of Aerospace, Mechanical and Mechatronic Engineering, University of Sydney, Sydney, New South Wales, Australia.
Charles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia.
Sydney Nano Institute, University of Sydney, Sydney, New South Wales, Australia.

Martin K C Ng (MKC)

Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.
Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.

Yin Xiao (Y)

Science and Engineering Faculty, Queensland University of Technology, Brisbane, Queensland, Australia.

Steven G Wise (SG)

Heart Research Institute, Sydney, New South Wales, Australia.
Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.

Classifications MeSH