Association Between Symptom Burden and Physical Function in Older Patients with Cancer.
Activities of Daily Living
Aged
Aged, 80 and over
Cognition
/ physiology
Cross-Sectional Studies
Exercise
/ physiology
Female
Follow-Up Studies
Geriatric Assessment
/ methods
Humans
Male
Mobility Limitation
Neoplasms
/ diagnosis
Prevalence
Prognosis
Retrospective Studies
Severity of Illness Index
United States
/ epidemiology
cancer
geriatric assessment
older patients
physical function
symptoms
Journal
Journal of the American Geriatrics Society
ISSN: 1532-5415
Titre abrégé: J Am Geriatr Soc
Pays: United States
ID NLM: 7503062
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
31
08
2018
revised:
21
12
2018
accepted:
07
02
2019
pubmed:
9
3
2019
medline:
15
5
2020
entrez:
9
3
2019
Statut:
ppublish
Résumé
To evaluate the independent association between symptom burden and physical function impairment in older adults with cancer. Cross-sectional. Two university-based geriatric oncology clinics. Patients with cancer aged 65 years or older who underwent evaluation with geriatric assessment (GA). Symptom burden was measured as a summary score of severity ratings (range = 0-10) of 10 commonly reported symptoms using a Clinical Symptom Inventory (CSI). Functional impairment was defined as the presence of one or more impairments of instrumental activities of daily living (IADLs), any significant physical activity limitation on the Medical Outcomes Survey (MOS), one or more recent falls in the previous 6 months, or a Short Physical Performance Battery (SPPB) score of 9 or less. Multivariate analysis evaluated the association between symptom burden and physical function impairment, adjusting for other clinical and sociodemographic variables. From 2011 to 2015, 359 patients with cancer and a median age of 81 years (range = 65-95 y) consented. The mean CSI score was 23.2 ± 20.5 with an observed range of 0 to 90. Patients in the highest quartile of symptom burden (N = 91; CSI score 52 ± 13) had a higher prevalence of IADL impairment (91% vs 51%), physical activity limitation (93% vs 65%), falls (55% vs 21%), and SPPB score of 9 or less (92% vs 69%) (all P values <.01) when compared with those in the bottom quartile (N = 81; CSI score: 2 ± 2). With each unit increase in CSI score, the odds of having IADL impairment, physical activity limitations, falls, and SPPB scores of 9 or less increased by 4.8%, 4.4%, 2.9%, and 2.5%, respectively (P < .05 for all results). In older patients with cancer, higher symptom burden is associated with functional impairment. Future studies are warranted to evaluate if improved symptom management can improve function in older cancer patients. J Am Geriatr Soc 67:998-1004, 2019.
Identifiants
pubmed: 30848838
doi: 10.1111/jgs.15864
pmc: PMC7851835
mid: NIHMS1660320
doi:
Types de publication
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
998-1004Subventions
Organisme : NIA NIH HHS
ID : K24 AG056589
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA177592
Pays : United States
Organisme : NIA NIH HHS
ID : R21 AG059206
Pays : United States
Organisme : NCI NIH HHS
ID : UG1 CA189961
Pays : United States
Informations de copyright
© 2019 The American Geriatrics Society.
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