An Error-Prone Polymerase in the Fight against Cancer.

Animals DNA-Directed DNA Polymerase / genetics Mice Mutagenesis Skin Neoplasms Ultraviolet Rays DNA Polymerase theta

Journal

Cell
ISSN: 1097-4172
Titre abrégé: Cell
Pays: United States
ID NLM: 0413066

Informations de publication

Date de publication:
07 03 2019
Historique:
entrez: 9 3 2019
pubmed: 9 3 2019
medline: 4 12 2019
Statut: ppublish

Résumé

Error-prone polymerases are alleged to induce mutations while replicating damaged DNA and to increase the risk of cancer. Using in vitro studies and mice models, Yoon et al. (2019) provide evidence that the error-prone Pol θ polymerase protects against ultraviolet light-induced skin cancer despite its mutagenic potential.

Identifiants

DOI: 10.1016/j.cell.2019.02.011 PMID: 30849368
pubmed: 30849368
pii: S0092-8674(19)30160-6
doi: 10.1016/j.cell.2019.02.011
pii:
doi:

Substances chimiques

DNA-Directed DNA Polymerase EC 2.7.7.7

Types de publication

Journal Article Research Support, Non-U.S. Gov't Comment

Langues

eng

Sous-ensembles de citation

IM

Pagination

1241-1243

Commentaires et corrections

Type : CommentOn

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

Auteurs

Yathish Jagadheesh Achar (YJ)

Fondazione Istituto FIRC di Oncologia Molecolare (IFOM), Via Adamello 16, 20139 Milan MI, Italy.

Marco Foiani (M)

Fondazione Istituto FIRC di Oncologia Molecolare (IFOM), Via Adamello 16, 20139 Milan MI, Italy; Università degli Studi di Milano, 20122 Milan MI, Italy. Electronic address: marco.foiani@ifom.eu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › An Error-Prone Polymerase in the Fight against Cancer.
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Nucleotidyltransferases › DNA nucleotidyltransferases › DNA-directed DNA polymerase › An Error-Prone Polymerase in the Fight against Cancer.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › An Error-Prone Polymerase in the Fight against Cancer.
questionsmedicales.fr › Phénomènes génétiques › Mutagenèse › An Error-Prone Polymerase in the Fight against Cancer.
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Tumeurs cutanées › An Error-Prone Polymerase in the Fight against Cancer.
questionsmedicales.fr › Environnement et santé publique › Environnement › Concepts météorologiques › Atmosphère › Temps (météorologie) › Lumière du soleil › Rayons ultraviolets › An Error-Prone Polymerase in the Fight against Cancer.