MEDUSA: A GPU-based tool to create realistic phantoms of the brain microstructure using tiny spheres.
Diffusion MRI
GPU
Phantom generation
White matter
Journal
NeuroImage
ISSN: 1095-9572
Titre abrégé: Neuroimage
Pays: United States
ID NLM: 9215515
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
08
11
2018
revised:
18
02
2019
accepted:
21
02
2019
pubmed:
9
3
2019
medline:
21
12
2019
entrez:
9
3
2019
Statut:
ppublish
Résumé
A GPU-based tool to generate realistic phantoms of the brain microstructure is presented. Using a spherical meshing technique which decomposes each microstructural item into a set of overlapping spheres, the phantom construction is made very fast while reliably avoiding the collisions between items in the scene. This novel method is applied to the construction of human brain white matter microstructural components, namely axonal fibers, oligodendrocytes and astrocytes. The algorithm reaches high values of packing density and angular dispersion for the axonal fibers, even in the case of multiple white matter fiber populations and enables the construction of complex biomimicking geometries including myelinated axons, beaded axons, and glial cells. The method can be readily adapted to model gray matter microstructure.
Identifiants
pubmed: 30849528
pii: S1053-8119(19)30151-X
doi: 10.1016/j.neuroimage.2019.02.055
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
10-24Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.