Tumor selective uptake of drug-nanodiamond complexes improves therapeutic outcome in pancreatic cancer.
Animals
Apoptosis
/ drug effects
Cell Line, Tumor
Doxorubicin
/ pharmacology
Drug Liberation
Endocytosis
/ drug effects
Humans
Hydrodynamics
Male
Mice
Nanodiamonds
/ chemistry
Pancreatic Neoplasms
/ drug therapy
Particle Size
Polyethylene Glycols
/ chemistry
Spheroids, Cellular
/ drug effects
Tissue Distribution
/ drug effects
Treatment Outcome
Drug delivery
Nanodiamonds
Nanomedicine
Pancreatic adenocarcinoma
Journal
Nanomedicine : nanotechnology, biology, and medicine
ISSN: 1549-9642
Titre abrégé: Nanomedicine
Pays: United States
ID NLM: 101233142
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
25
07
2018
revised:
25
11
2018
accepted:
05
02
2019
pubmed:
9
3
2019
medline:
4
12
2019
entrez:
9
3
2019
Statut:
ppublish
Résumé
Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer-related deaths and novel treatment approaches are urgently needed. Here we show that poly(ethylene glycol)-functionalized nanodiamonds loaded with doxorubicin (ND-PEG-DOX) afforded a considerable improvement over free drug in an orthotopic pancreatic xenograft model. ND-PEG-DOX complexes were also superior to free DOX in 3-dimensional (3D) tumor spheroids of PDAC. ND-PEG showed no cytotoxicity towards macrophages, and histopathological analysis showed no abnormalities of major organs upon in vivo administration of ND-PEG-DOX. These results provide evidence that ND-mediated drug delivery may serve as a means of improving the therapeutic outcome in PDAC.
Identifiants
pubmed: 30849547
pii: S1549-9634(19)30051-6
doi: 10.1016/j.nano.2019.02.020
pmc: PMC6588439
mid: NIHMS1523284
pii:
doi:
Substances chimiques
Nanodiamonds
0
Polyethylene Glycols
3WJQ0SDW1A
Doxorubicin
80168379AG
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
112-121Subventions
Organisme : NCI NIH HHS
ID : R01 CA078383
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA150190
Pays : United States
Organisme : NCI NIH HHS
ID : R29 CA078383
Pays : United States
Informations de copyright
Copyright © 2019 The Author(s). Published by Elsevier Inc. All rights reserved.
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