MAPKAPK2: the master regulator of RNA-binding proteins modulates transcript stability and tumor progression.
3′-untranslated region (3′-UTR)
Adenine/uridine-rich elements (AREs)
Inhibitors
Mitogen-activated protein kinase-activated protein kinase 2 (MK2)
RNA binding proteins (RBPs)
Therapeutics
Transcript stability
Journal
Journal of experimental & clinical cancer research : CR
ISSN: 1756-9966
Titre abrégé: J Exp Clin Cancer Res
Pays: England
ID NLM: 8308647
Informations de publication
Date de publication:
08 Mar 2019
08 Mar 2019
Historique:
received:
06
12
2018
accepted:
21
02
2019
entrez:
10
3
2019
pubmed:
10
3
2019
medline:
21
6
2019
Statut:
epublish
Résumé
The p38 mitogen-activated protein kinase (p38MAPK) pathway has been implicated in a variety of pathological conditions including inflammation and metastasis. Post-transcriptional regulation of genes harboring adenine/uridine-rich elements (AREs) in their 3'-untranslated region (3'-UTR) is controlled by MAPK-activated protein kinase 2 (MAPKAPK2 or MK2), a downstream substrate of the p38MAPK. In response to diverse extracellular stimuli, MK2 influences crucial signaling events, regulates inflammatory cytokines, transcript stability and critical cellular processes. Expression of genes involved in these vital cellular cascades is controlled by subtle interactions in underlying molecular networks and post-transcriptional gene regulation that determines transcript fate in association with RNA-binding proteins (RBPs). Several RBPs associate with the 3'-UTRs of the target transcripts and regulate their expression via modulation of transcript stability. Although MK2 regulates important cellular phenomenon, yet its biological significance in tumor progression has not been well elucidated till date. In this review, we have highlighted in detail the importance of MK2 as the master regulator of RBPs and its role in the regulation of transcript stability, tumor progression, as well as the possibility of use of MK2 as a therapeutic target in tumor management.
Identifiants
pubmed: 30850014
doi: 10.1186/s13046-019-1115-1
pii: 10.1186/s13046-019-1115-1
pmc: PMC6408796
doi:
Substances chimiques
Intracellular Signaling Peptides and Proteins
0
RNA-Binding Proteins
0
MAP-kinase-activated kinase 2
EC 2.7.1.-
Protein Serine-Threonine Kinases
EC 2.7.11.1
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
121Subventions
Organisme : Council of Scientific and Industrial Research
ID : MLP0204
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