Innate Control of Tissue-Reparative Human Regulatory T Cells.
Journal
Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R
Informations de publication
Date de publication:
15 04 2019
15 04 2019
Historique:
received:
01
10
2018
accepted:
23
01
2019
pubmed:
10
3
2019
medline:
28
12
2019
entrez:
10
3
2019
Statut:
ppublish
Résumé
Regulatory T cell (Treg) therapy is a potential curative approach for a variety of immune-mediated conditions, including autoimmunity and transplantation, in which there is pathological tissue damage. In mice, IL-33R (ST2)-expressing Tregs mediate tissue repair by producing the growth factor amphiregulin, but whether similar tissue-reparative Tregs exist in humans remains unclear. We show that human Tregs in blood and multiple tissue types produced amphiregulin, but this was neither a unique feature of Tregs nor selectively upregulated in tissues. Human Tregs in blood, tonsil, synovial fluid, colon, and lung tissues did not express ST2, so ST2
Identifiants
pubmed: 30850479
pii: jimmunol.1801330
doi: 10.4049/jimmunol.1801330
doi:
Substances chimiques
IL1RL1 protein, human
0
IL33 protein, human
0
Interleukin-1 Receptor-Like 1 Protein
0
Interleukin-33
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2195-2209Subventions
Organisme : CIHR
ID : FDN-154304
Pays : Canada
Organisme : Arthritis Research UK
Pays : United Kingdom
Informations de copyright
Copyright © 2019 by The American Association of Immunologists, Inc.