Amino Acid Motifs
Animals
Cell Adhesion
Cell Movement
Coordination Complexes
/ chemistry
Dermatitis
/ diagnostic imaging
Female
Immunohistochemistry
Inflammation
Integrin alphaVbeta3
/ metabolism
Intracellular Signaling Peptides and Proteins
/ metabolism
Male
Melanoma
/ diagnostic imaging
Melanoma, Experimental
Mice
Mice, Inbred C57BL
Microscopy, Fluorescence
Mutation
Neoplasm Metastasis
Neoplasm Transplantation
Peptides, Cyclic
/ chemistry
Positron Emission Tomography Computed Tomography
Skin Neoplasms
/ diagnostic imaging
Up-Regulation
PET
RGD
SHARPIN
melanoma
αvβ3 integrin
Journal
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
ISSN: 1535-5667
Titre abrégé: J Nucl Med
Pays: United States
ID NLM: 0217410
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
17
10
2018
accepted:
04
03
2019
pubmed:
10
3
2019
medline:
14
4
2020
entrez:
10
3
2019
Statut:
ppublish
Résumé
Shank-associated RH domain-interacting protein (SHARPIN) is a cytosolic protein that plays a key role in activation of nuclear factor κ-light-chain enhancer of activated B cells and regulation of inflammation. Furthermore, SHARPIN controls integrin-dependent cell adhesion and migration in several normal and malignant cell types, and loss of SHARPIN correlates with increased integrin activity in mice. Arginyl-glycyl-aspartic acid (RGD), a cell adhesion tripeptide motif, is an integrin recognition sequence that facilitates PET imaging of integrin upregulation during tumor angiogenesis. We hypothesized that increased integrin activity due to loss of SHARPIN protein would affect the uptake of α
Identifiants
pubmed: 30850498
pii: jnumed.118.222026
doi: 10.2967/jnumed.118.222026
pmc: PMC6785786
doi:
Substances chimiques
68Ga-DOTA-E-(c(RGDfK))2
0
Coordination Complexes
0
Integrin alphaVbeta3
0
Intracellular Signaling Peptides and Proteins
0
Peptides, Cyclic
0
Sipl1 protein, mouse
0
cyclic arginine-glycine-aspartic acid peptide
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1380-1387Informations de copyright
© 2019 by the Society of Nuclear Medicine and Molecular Imaging.
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