Novelty processing and memory impairment in Alzheimer's disease: A review.
Alzheimer's disease
Hippocampus
Memory
Novelty detection
Journal
Neuroscience and biobehavioral reviews
ISSN: 1873-7528
Titre abrégé: Neurosci Biobehav Rev
Pays: United States
ID NLM: 7806090
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
10
09
2018
revised:
24
12
2018
accepted:
28
02
2019
pubmed:
10
3
2019
medline:
27
6
2019
entrez:
10
3
2019
Statut:
ppublish
Résumé
The detection and processing of novelty plays a critical role in memory function. Despite this, relatively little is known about how novelty influences memory in Alzheimer's disease (AD). This review sought to address whether AD patients are still sensitive to novelty; whether novelty triggers memory processes as is observed in healthy subjects; and whether it is possible to promote novelty to enhance memory at the different stages of AD. The studies reviewed showed that novelty processing is mostly impaired in AD patients, whereas it can be preserved under some conditions in MCI, particularly when cognitive demands are otherwise low. We further identify outstanding questions that should be addressed in the near future in order to more robustly establish the fate of novelty processing and detection in the course of AD. Doing so would allow to improve current models of memory impairment in AD, leading to a more comprehensive view of the sources of memory decline and could lead to neuropsychological and/or pharmaceutical rehabilitation programs.
Identifiants
pubmed: 30851282
pii: S0149-7634(18)30680-8
doi: 10.1016/j.neubiorev.2019.02.021
pii:
doi:
Substances chimiques
Dopamine
VTD58H1Z2X
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
237-249Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.