Plugged into the Ku-DNA hub: The NHEJ network.
Conserved binding motifs
DNA damage
DNA repair machineries
Double-strand breaks
Ku
NHEJ
Protein interactions network
Journal
Progress in biophysics and molecular biology
ISSN: 1873-1732
Titre abrégé: Prog Biophys Mol Biol
Pays: England
ID NLM: 0401233
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
31
10
2018
revised:
26
02
2019
accepted:
01
03
2019
pubmed:
10
3
2019
medline:
19
5
2020
entrez:
10
3
2019
Statut:
ppublish
Résumé
In vertebrates, double-strand breaks in DNA are primarily repaired by Non-Homologous End-Joining (NHEJ). The ring-shaped Ku heterodimer rapidly senses and threads onto broken DNA ends forming a recruiting hub. Through protein-protein contacts eventually reinforced by protein-DNA interactions, the Ku-DNA hub attracts a series of specialized proteins with scaffolding and/or enzymatic properties. To shed light on these dynamic interplays, we review here current knowledge on proteins directly interacting with Ku and on the contact points involved, with a particular accent on the different classes of Ku-binding motifs identified in several Ku partners. An integrated structural model of the core NHEJ network at the synapsis step is proposed.
Identifiants
pubmed: 30851288
pii: S0079-6107(18)30251-7
doi: 10.1016/j.pbiomolbio.2019.03.001
pii:
doi:
Substances chimiques
DNA
9007-49-2
Ku Autoantigen
EC 4.2.99.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
62-76Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.