Maturation of the respiratory complex II flavoprotein.

Animals Cell Respiration Electron Transport Chain Complex Proteins / chemistry Electron Transport Complex II / chemistry Flavin-Adenine Dinucleotide / biosynthesis Flavoproteins / chemistry Humans Protein Binding Protein Subunits Structure-Activity Relationship

Journal

Current opinion in structural biology
ISSN: 1879-033X
Titre abrégé: Curr Opin Struct Biol
Pays: England
ID NLM: 9107784

Informations de publication

Date de publication:
12 2019
Historique:
received: 29 01 2019
accepted: 31 01 2019
pubmed: 10 3 2019
medline: 4 8 2020
entrez: 10 3 2019
Statut: ppublish

Résumé

Respiratory complexes are complicated multi-subunit cofactor-containing machines that allow cells to harvest energy from the environment. Maturation of these complexes requires protein folding, cofactor insertion, and assembly of multiple subunits into a final, functional complex. Because the intermediate states in complex maturation are transitory, these processes are poorly understood. This review gives an overview of the process of maturation in respiratory complex II with a focus on recent structural studies on intermediates formed during covalent flavinylation of the catalytic subunit, SDHA. Covalent flavinylation has an evolutionary significance because variants of complex II enzymes with the covalent ligand removed by mutagenesis cannot oxidize succinate, but can still perform the reverse reaction and reduce fumarate. Since succinate oxidation is a key step of aerobic respiration, the covalent bond of complex II appears to be important for aerobic life.

Identifiants

DOI: 10.1016/j.sbi.2019.01.027 PMID: 30851631 PMC: PMC6731172
pubmed: 30851631
pii: S0959-440X(18)30142-8
doi: 10.1016/j.sbi.2019.01.027
pmc: PMC6731172
mid: NIHMS1523364
pii:
doi:

Substances chimiques

Electron Transport Chain Complex Proteins 0
Flavoproteins 0
Protein Subunits 0
respiratory complex II 0
Flavin-Adenine Dinucleotide 146-14-5
Electron Transport Complex II EC 1.3.5.1
SDHA protein, human EC 1.3.5.1

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

38-46

Subventions

Organisme : BLRD VA
ID : IK6 BX004215
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK058404
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM061606
Pays : United States

Informations de copyright

Copyright © 2019 Elsevier Ltd. All rights reserved.

Références

J Biol Chem. 1996 Feb 23;271(8):4061-7
pubmed: 8626740
Plant Physiol. 2018 Aug;177(4):1439-1452
pubmed: 29930107
FEBS J. 2008 Oct;275(20):5191-200
pubmed: 18793324
Cell Metab. 2014 Aug 5;20(2):253-66
pubmed: 24954417
J Mol Biol. 2010 May 21;398(5):641-6
pubmed: 20359485
Protein Sci. 1998 Jan;7(1):7-20
pubmed: 9514256
J Biol Chem. 2017 Aug 4;292(31):12921-12933
pubmed: 28615448
Nat Commun. 2018 Jan 18;9(1):274
pubmed: 29348404
Biochim Biophys Acta. 2013 May;1827(5):627-36
pubmed: 23380393
Semin Cell Dev Biol. 2018 Apr;76:163-178
pubmed: 28870773
Mol Biol Cell. 2011 Jul 1;22(13):2135-43
pubmed: 21525245
Nat Rev Mol Cell Biol. 2010 Sep;11(9):655-67
pubmed: 20729931
J Biol Chem. 1996 Mar 29;271(13):7392-7
pubmed: 8631763
Cell Metab. 2014 Aug 5;20(2):241-52
pubmed: 24954416
J Mol Biol. 2010 Jul 9;400(2):218-30
pubmed: 20471397
J Biol Chem. 2011 Jan 28;286(4):3047-56
pubmed: 21098488
J Biol Chem. 2012 May 25;287(22):18418-28
pubmed: 22474332
Proteins. 2008 Jan 1;70(1):83-92
pubmed: 17634981
Mol Cell Biol. 1995 Jan;15(1):264-71
pubmed: 7799934
J Biol Chem. 2012 Oct 12;287(42):35430-8
pubmed: 22904323
Crit Rev Biochem Mol Biol. 2015 Mar-Apr;50(2):168-80
pubmed: 25488574
Science. 2009 Aug 28;325(5944):1139-42
pubmed: 19628817
Science. 1999 Jun 18;284(5422):1961-6
pubmed: 10373108
Essays Biochem. 2018 Jul 20;62(3):255-270
pubmed: 30030361
J Biol Chem. 1998 Nov 27;273(48):32042-8
pubmed: 9822678
Nat Genet. 2009 Jun;41(6):654-6
pubmed: 19465911
FEBS Lett. 1996 Jun 24;389(1):25-31
pubmed: 8682198
Cell. 2005 Jul 1;121(7):1043-57
pubmed: 15989954
Biochemistry. 2013 Oct 29;52(43):7628-40
pubmed: 24070374
Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):2982-2987
pubmed: 29514959
J Biol Chem. 2000 Sep 15;275(37):28618-24
pubmed: 10887197
Biochemistry. 2003 Nov 4;42(43):12532-8
pubmed: 14580199
J Biol Chem. 1996 Feb 23;271(8):4055-60
pubmed: 8626739
Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15304-9
pubmed: 14673090
Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2617-22
pubmed: 16469842
Nat Commun. 2017 Nov 3;8(1):1287
pubmed: 29097656
Nature. 2016 Oct 20;538(7625):406-410
pubmed: 27595392
Biochim Biophys Acta. 2012 Feb;1817(2):276-86
pubmed: 22138626
J Biol Chem. 2006 Mar 3;281(9):5965-72
pubmed: 16371358
J Biol Chem. 2004 Jan 2;279(1):95-102
pubmed: 14555654
Eur J Biochem. 1989 Jun 1;182(1):125-8
pubmed: 2659351
Essays Biochem. 2010;47:1-23
pubmed: 20533897
Biochemistry. 2012 Oct 30;51(43):8475-7
pubmed: 23062074
Biochemistry. 2008 Jan 29;47(4):1136-43
pubmed: 18179257
Biochim Biophys Acta. 2002 Sep 2;1592(1):63-77
pubmed: 12191769
J Biol Chem. 2016 Feb 5;291(6):2904-16
pubmed: 26644464
Science. 2017 Nov 17;358(6365):936-940
pubmed: 29074581
Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):2850-2852
pubmed: 29514954
PLoS One. 2016 Jul 06;11(7):e0158749
pubmed: 27382962
J Biol Chem. 2018 May 18;293(20):7754-7765
pubmed: 29610278
Arch Biochem Biophys. 2016 Aug 15;604:47-56
pubmed: 27296776
Biochim Biophys Acta. 2012 Jun;1817(6):851-62
pubmed: 21924235
Cell. 2017 Sep 7;170(6):1247-1257.e12
pubmed: 28844695

Auteurs

Pankaj Sharma (P)

Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, United States.

Elena Maklashina (E)

Molecular Biology Division, San Francisco VA Health Care System, San Francisco, CA 94121, United States; Department of Biochemistry & Biophysics, University of California, San Francisco, CA 94158, United States.

Gary Cecchini (G)

Molecular Biology Division, San Francisco VA Health Care System, San Francisco, CA 94121, United States; Department of Biochemistry & Biophysics, University of California, San Francisco, CA 94158, United States. Electronic address: gary.cecchini@ucsf.edu.

T M Iverson (TM)

Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, United States; Department of Biochemistry, Vanderbilt University, Nashville, TN 37232, United States; Center for Structural Biology, Vanderbilt University, Nashville, TN 37232, United States; Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN 37232, United States. Electronic address: tina.iverson@vanderbilt.edu.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Maturation of the respiratory complex II flavoprotein.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Respiration cellulaire › Maturation of the respiratory complex II flavoprotein.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Complexe enzymatique de la chaine respiratoire mitochondriale › Maturation of the respiratory complex II flavoprotein.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Métalloprotéines › Protéines de liaison au fer › Protéines à fer non hème › Ferrosulfoprotéines › Complexe II de la chaîne respiratoire › Maturation of the respiratory complex II flavoprotein.
questionsmedicales.fr › Facteurs biologiques › Pigments biologiques › Flavines › Riboflavine › Flavine adénine dinucléotide › Maturation of the respiratory complex II flavoprotein.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Flavoprotéines › Maturation of the respiratory complex II flavoprotein.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Maturation of the respiratory complex II flavoprotein.
questionsmedicales.fr › Métabolisme › Liaison aux protéines › Maturation of the respiratory complex II flavoprotein.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Sous-unités de protéines › Maturation of the respiratory complex II flavoprotein.
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Maturation of the respiratory complex II flavoprotein.