Synthesis and pharmacological evaluation of novel arylpiperazine oxicams derivatives as potent analgesics without ulcerogenicity.
1,2-Benzothiazine
Analgesic activity
Oxicams
Synthesis
Ulcerogenicity
Journal
Bioorganic & medicinal chemistry
ISSN: 1464-3391
Titre abrégé: Bioorg Med Chem
Pays: England
ID NLM: 9413298
Informations de publication
Date de publication:
15 04 2019
15 04 2019
Historique:
received:
10
09
2018
revised:
26
02
2019
accepted:
02
03
2019
pubmed:
11
3
2019
medline:
18
2
2020
entrez:
11
3
2019
Statut:
ppublish
Résumé
Gastrotoxicity continues to be a major issue in therapy with nonsteroidal anti-inflammatory drugs (NSAIDs). Medicine is yet to develop absolutely safe analgesics. Numerous strategies are employed to discover new, safer NSAIDs, for example selective inhibition of cyclooxygenase-2, new molecular targets (e.g. microsomal prostaglandin E
Identifiants
pubmed: 30852078
pii: S0968-0896(18)31601-8
doi: 10.1016/j.bmc.2019.03.007
pii:
doi:
Substances chimiques
Analgesics
0
Anti-Inflammatory Agents, Non-Steroidal
0
Piperazines
0
Piroxicam
13T4O6VMAM
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1619-1628Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.