Increased Prevalence of Hepatic Steatosis in Young Adults With Lifelong HIV.
AIDS
HIV
hepatic steatosis
nonalcoholic fatty liver disease
young adults
Journal
The Journal of infectious diseases
ISSN: 1537-6613
Titre abrégé: J Infect Dis
Pays: United States
ID NLM: 0413675
Informations de publication
Date de publication:
19 06 2019
19 06 2019
Historique:
received:
03
01
2019
accepted:
05
03
2019
pubmed:
11
3
2019
medline:
25
2
2020
entrez:
11
3
2019
Statut:
ppublish
Résumé
Little is known about the effects of lifelong human immunodeficiency virus (HIV) or antiretroviral therapy on hepatic steatosis and fibrosis. Using transient elastography, we evaluated 46 young adults with lifelong HIV and 20 matched HIV-negative controls. Steatosis was present in 33% of persons with HIV and only 10% of controls (P = .04). Hepatic fibrosis scores were not elevated and did not differ between groups. Metabolic parameters, particularly increased waist circumference, and not HIV-specific factors, were significantly associated with steatosis. While this finding should be examined in larger cohorts, modifiable metabolic disturbances may be important targets to optimize liver health in this population.
Identifiants
pubmed: 30852587
pii: 5372968
doi: 10.1093/infdis/jiz096
pmc: PMC6581896
doi:
Banques de données
ClinicalTrials.gov
['NCT01656564']
Types de publication
Clinical Trial
Journal Article
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
266-269Informations de copyright
Published by Oxford University Press for the Infectious Diseases Society of America 2019.
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