CROCC-mutated rhabdoid colorectal carcinoma showing in intercellular spaces lamellipodia and cellular projections revealed by electron microscopy.
CROCC
Ciliary Rootlet Coiled Coil
Intermediate filaments
Lamellipodia
Nucleolar margination
ROLT
Rhabdoid colorectal carcinoma
SMARCB1
SWI/SNF
Scanning electron microscopy
TAX1BP2
Transmission electron microscopy
Journal
Virchows Archiv : an international journal of pathology
ISSN: 1432-2307
Titre abrégé: Virchows Arch
Pays: Germany
ID NLM: 9423843
Informations de publication
Date de publication:
Aug 2019
Aug 2019
Historique:
received:
13
12
2018
accepted:
28
02
2019
revised:
16
02
2019
pubmed:
11
3
2019
medline:
28
7
2019
entrez:
11
3
2019
Statut:
ppublish
Résumé
Rhabdoid colorectal carcinoma (RC) is a rare lesion localized to the proximal colon of patients with a mean age at diagnosis of around 70 years. This tumor shows an aggressive behavior with an overall survival period shorter than 12 months. The diagnostic hallmark is the presence of rhabdoid cells. Alterations in chromatin remodeling (SMARCB1) and in the centrosome structure (CROCC) are reported in RC usually BRAF Here, we investigated two cases of CROCC TEM confirmed the diagnostic presence of intermediate cytoplasmic filaments and nucleolar margination. SEM showed cellular protrusions (lamellipodia) in the intercellular spaces not evident at light microscopy. These protrusions CROCC-related might represent the pathogenetic mechanism underlying the rhabdoid aggressive behavior, independently of tumor staging. To our knowledge, the SEM technique was applied in the study of this neoplasm for the first time.
Sections du résumé
BACKGROUND
BACKGROUND
Rhabdoid colorectal carcinoma (RC) is a rare lesion localized to the proximal colon of patients with a mean age at diagnosis of around 70 years. This tumor shows an aggressive behavior with an overall survival period shorter than 12 months. The diagnostic hallmark is the presence of rhabdoid cells. Alterations in chromatin remodeling (SMARCB1) and in the centrosome structure (CROCC) are reported in RC usually BRAF
METHODS
METHODS
Here, we investigated two cases of CROCC
RESULTS
RESULTS
TEM confirmed the diagnostic presence of intermediate cytoplasmic filaments and nucleolar margination. SEM showed cellular protrusions (lamellipodia) in the intercellular spaces not evident at light microscopy.
CONCLUSIONS
CONCLUSIONS
These protrusions CROCC-related might represent the pathogenetic mechanism underlying the rhabdoid aggressive behavior, independently of tumor staging. To our knowledge, the SEM technique was applied in the study of this neoplasm for the first time.
Identifiants
pubmed: 30852641
doi: 10.1007/s00428-019-02554-4
pii: 10.1007/s00428-019-02554-4
doi:
Substances chimiques
CROCC protein, human
0
Cytoskeletal Proteins
0
Types de publication
Journal Article
Langues
eng
Pagination
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