Kinetics of Alphatorquevirus plasma DNAemia at late times after allogeneic hematopoietic stem cell transplantation.


Journal

Medical microbiology and immunology
ISSN: 1432-1831
Titre abrégé: Med Microbiol Immunol
Pays: Germany
ID NLM: 0314524

Informations de publication

Date de publication:
Apr 2019
Historique:
received: 31 10 2018
accepted: 21 02 2019
pubmed: 11 3 2019
medline: 23 4 2019
entrez: 11 3 2019
Statut: ppublish

Résumé

Torque teno virus (TTV) plasma DNA load has been consistently shown to be a surrogate biomarker of immunosuppression in solid organ transplant recipients. It is uncertain whether it may behave similarly in allogeneic hematopoietic stem cell transplant recipients (allo-HSCT). Here, we characterized the dynamics of TTV DNAemia in patients undergoing T-cell replete allo-SCT at late times after transplantation (> day + 100). This retrospective single-center observational study included 33 allo-HSCT patients. Plasma TTV DNA loads were quantified by real-time PCR before initiating the conditioning regimen and at different time points after transplant. Absolute lymphocyte counts (ALC) were measured by flow cytometry. Overall, TTV DNA load increased steadily after engraftment, reaching a peak by day + 90; afterwards, it remained relatively constant until day + 210. TTV DNA loads measured within days + 120 and + 210 correlated inversely with paired ALC, while both parameters did correlate directly within days + 20 and + 60. The median TTV DNA area under a curve between days + 90 and + 210 [(AUC)

Identifiants

pubmed: 30852649
doi: 10.1007/s00430-019-00586-w
pii: 10.1007/s00430-019-00586-w
doi:

Substances chimiques

DNA, Viral 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

253-258

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Auteurs

Eliseo Albert (E)

Microbiology Service, Hospital Clínico Universitario, Institute for Research INCLIVA, Valencia, Spain.

Carlos Solano (C)

Hematology Service, Hospital Clínico Universitario, Institute for Research INCLIVA, Valencia, Spain.
Department of Medicine, School of Medicine, University of Valencia, Valencia, Spain.

Estela Giménez (E)

Microbiology Service, Hospital Clínico Universitario, Institute for Research INCLIVA, Valencia, Spain.

Daniele Focosi (D)

North-Western Tuscany Blood Bank, Pisa University Hospital, Pisa, Italy.

Ariadna Pérez (A)

Hematology Service, Hospital Clínico Universitario, Institute for Research INCLIVA, Valencia, Spain.

Lisa Macera (L)

Virology Unit, Pisa University Hospital, Pisa, Italy.

José Luis Piñana (JL)

Hematology Service, Hospital Clínico Universitario, Institute for Research INCLIVA, Valencia, Spain.

Eva María Mateo (EM)

Microbiology Service, Hospital Clínico Universitario, Institute for Research INCLIVA, Valencia, Spain.

Juan Carlos Hernández Boluda (JCH)

Hematology Service, Hospital Clínico Universitario, Institute for Research INCLIVA, Valencia, Spain.

Fabrizio Maggi (F)

Virology Unit, Pisa University Hospital, Pisa, Italy.
Department of Translational Research, University of Pisa, Pisa, Italy.

David Navarro (D)

Microbiology Service, Hospital Clínico Universitario, Institute for Research INCLIVA, Valencia, Spain. david.navarro@uv.es.
Department of Microbiology, School of Medicine, University of Valencia, Av. Blasco Ibáñez 17, 46010, Valencia, Spain. david.navarro@uv.es.

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Classifications MeSH