Kinetics of Alphatorquevirus plasma DNAemia at late times after allogeneic hematopoietic stem cell transplantation.
Adolescent
Adult
Aged
DNA Virus Infections
/ virology
DNA, Viral
/ blood
Female
Flow Cytometry
Hematopoietic Stem Cell Transplantation
/ adverse effects
Humans
Lymphocyte Count
Male
Middle Aged
Plasma
/ virology
Real-Time Polymerase Chain Reaction
Retrospective Studies
Time Factors
Torque teno virus
/ isolation & purification
Transplantation, Homologous
/ adverse effects
Young Adult
Allogeneic hematopoietic stem cell transplantation
Biomarker
Immunosuppression
Torque teno virus (TTV) DNAemia
Journal
Medical microbiology and immunology
ISSN: 1432-1831
Titre abrégé: Med Microbiol Immunol
Pays: Germany
ID NLM: 0314524
Informations de publication
Date de publication:
Apr 2019
Apr 2019
Historique:
received:
31
10
2018
accepted:
21
02
2019
pubmed:
11
3
2019
medline:
23
4
2019
entrez:
11
3
2019
Statut:
ppublish
Résumé
Torque teno virus (TTV) plasma DNA load has been consistently shown to be a surrogate biomarker of immunosuppression in solid organ transplant recipients. It is uncertain whether it may behave similarly in allogeneic hematopoietic stem cell transplant recipients (allo-HSCT). Here, we characterized the dynamics of TTV DNAemia in patients undergoing T-cell replete allo-SCT at late times after transplantation (> day + 100). This retrospective single-center observational study included 33 allo-HSCT patients. Plasma TTV DNA loads were quantified by real-time PCR before initiating the conditioning regimen and at different time points after transplant. Absolute lymphocyte counts (ALC) were measured by flow cytometry. Overall, TTV DNA load increased steadily after engraftment, reaching a peak by day + 90; afterwards, it remained relatively constant until day + 210. TTV DNA loads measured within days + 120 and + 210 correlated inversely with paired ALC, while both parameters did correlate directly within days + 20 and + 60. The median TTV DNA area under a curve between days + 90 and + 210 [(AUC)
Identifiants
pubmed: 30852649
doi: 10.1007/s00430-019-00586-w
pii: 10.1007/s00430-019-00586-w
doi:
Substances chimiques
DNA, Viral
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
253-258Références
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