Coagulation Factor XIIIa Inhibitor Tridegin: On the Role of Disulfide Bonds for Folding, Stability, and Function.
Journal
Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531
Informations de publication
Date de publication:
11 04 2019
11 04 2019
Historique:
pubmed:
12
3
2019
medline:
15
9
2020
entrez:
12
3
2019
Statut:
ppublish
Résumé
Tridegin is a potent and specific 66mer peptide inhibitor of coagulation factor XIIIa with six cysteines involved in three disulfide bonds. Three of the 15 possible 3-disulfide-bonded isomers have been identified, which share a bridge between cysteines 19 and 25. We synthesized the three possible 2-disulfide-bonded analogues using a targeted protecting group strategy to investigate the impact of the C
Identifiants
pubmed: 30852892
doi: 10.1021/acs.jmedchem.8b01982
pmc: PMC6650289
mid: NIHMS1025460
doi:
Substances chimiques
Disulfides
0
Salivary Proteins and Peptides
0
tridegin
0
Factor XIIIa
EC 2.3.2.13
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3513-3523Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL126974
Pays : United States
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