Modulation of urinary frequency via type 1 lysophosphatidic acid receptors: Effect of the novel antagonist ASP6432 in conscious rats.

Animals Benzamides Consciousness Dose-Response Relationship, Drug Female Rats Rats, Sprague-Dawley Receptors, Lysophosphatidic Acid / antagonists & inhibitors Thiazoles / pharmacology Urinary Bladder, Overactive / physiopathology Urination / drug effects
Bladder overactivity Cystometry LPA(1) receptor Lysophosphatidic acid Storage symptoms

Journal

European journal of pharmacology
ISSN: 1879-0712
Titre abrégé: Eur J Pharmacol
Pays: Netherlands
ID NLM: 1254354

Informations de publication

Date de publication:
15 Jun 2019
Historique:
received: 20 12 2018
revised: 25 02 2019
accepted: 06 03 2019
pubmed: 12 3 2019
medline: 10 9 2019
entrez: 12 3 2019
Statut: ppublish

Résumé

Bladder dysfunctions associated with benign prostatic hyperplasia are not sufficiently alleviated by current pharmacotherapies. Lysophosphatidic acid (LPA) is a phospholipid with diverse biological effects. LPA modulates prostate and urethral contraction via the type 1 LPA (LPA

Identifiants

DOI: 10.1016/j.ejphar.2019.03.011 PMID: 30853531
pubmed: 30853531
pii: S0014-2999(19)30160-8
doi: 10.1016/j.ejphar.2019.03.011
pii:
doi:

Substances chimiques

ASP6432 0
Benzamides 0
Receptors, Lysophosphatidic Acid 0
Thiazoles 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

11-17

Informations de copyright

Copyright © 2019 Elsevier B.V. All rights reserved.

Auteurs

Kazuyuki Sakamoto (K)

Drug Discovery Research, Astellas Pharma Inc., Japan. Electronic address: kazuyuki.sakamoto@astellas.com.

Yukiko Noguchi (Y)

Drug Discovery Research, Astellas Pharma Inc., Japan.

Koji Ueshima (K)

Drug Discovery Research, Astellas Pharma Inc., Japan.

Akiyoshi Ohtake (A)

Drug Discovery Research, Astellas Pharma Inc., Japan.

Shuichi Sato (S)

Drug Discovery Research, Astellas Pharma Inc., Japan.

Katsunori Imazumi (K)

Drug Discovery Research, Astellas Pharma Inc., Japan.

Masahiro Takeda (M)

Drug Discovery Research, Astellas Pharma Inc., Japan.

Noriyuki Masuda (N)

Drug Discovery Research, Astellas Pharma Inc., Japan.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Modulation of urinary frequency via type 1...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Benzoates › Benzamides › Modulation of urinary frequency via type 1...
questionsmedicales.fr › Phénomènes psychologiques › Conscience › Modulation of urinary frequency via type 1...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › Modulation of urinary frequency via type 1...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Modulation of urinary frequency via type 1...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Sprague-Dawley › Modulation of urinary frequency via type 1...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › Récepteurs aux lysophospholipides › Récepteurs à l'acide phosphatidique › Modulation of urinary frequency via type 1...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Thiazoles › Modulation of urinary frequency via type 1...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations urologiques › Symptômes de l'appareil urinaire inférieur › Vessie hyperactive › Modulation of urinary frequency via type 1...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques des voies urinaires › Miction › Modulation of urinary frequency via type 1...