Stronger together: Multi-genome transmission of measles virus.
Cyclical adaptation
Epithelial spread
Measles virus
Quasispecies
Tissue adaptation
Virus transmission
Journal
Virus research
ISSN: 1872-7492
Titre abrégé: Virus Res
Pays: Netherlands
ID NLM: 8410979
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
29
01
2019
revised:
04
03
2019
accepted:
05
03
2019
pubmed:
12
3
2019
medline:
20
8
2019
entrez:
12
3
2019
Statut:
ppublish
Résumé
Measles virus (MeV) is an immunosuppressive, extremely contagious RNA virus that remains a leading cause of death among children. MeV is dual-tropic: it replicates first in lymphatic tissue, causing immunosuppression, and then in epithelial cells of the upper airways, accounting for extremely efficient contagion. Efficient contagion is counter-intuitive because the enveloped MeV particles are large and relatively unstable. However, MeV particles can contain multiple genomes, which can code for proteins with different functional characteristics. These proteins can cooperate to promote virus spread in tissue culture, prompting the question of whether multi-genome MeV transmission may promote efficient MeV spread also in vivo. Consistent with this hypothesis, in well-differentiated primary human airway epithelia large genome populations spread rapidly through intercellular pores. In another line of research, it was shown that distinct lymphocytic-adapted and epithelial-adapted genome populations exist; cyclical adaptation studies indicate that suboptimal variants in one environment may constitute a low frequency reservoir for adaptation to the other environment. Altogether, these observations suggest that, in humans, MeV spread relies on en bloc genome transmission, and that genomic diversity is instrumental for rapid MeV dissemination within hosts.
Identifiants
pubmed: 30853585
pii: S0168-1702(19)30066-8
doi: 10.1016/j.virusres.2019.03.007
pmc: PMC6461485
mid: NIHMS1524050
pii:
doi:
Substances chimiques
Receptors, Virus
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Pagination
74-79Subventions
Organisme : NIAID NIH HHS
ID : R21 AI125747
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI128037
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI132165
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.
Références
Virology. 1997 Jun 23;233(1):74-84
pubmed: 9201218
PLoS Biol. 2018 Nov 29;16(11):e2006577
pubmed: 30496178
Curr Opin Virol. 2014 Apr;5:16-23
pubmed: 24492202
Cell. 1988 Dec 23;55(6):1089-98
pubmed: 3203381
J Virol. 2010 Apr;84(7):3413-20
pubmed: 20071568
Cell. 1989 Mar 10;56(5):759-64
pubmed: 2924348
J Virol. 2010 Nov;84(21):11152-63
pubmed: 20719949
J Virol. 2016 Jul 11;90(15):6808-6817
pubmed: 27194761
Proc Natl Acad Sci U S A. 1989 Apr;86(8):2647-51
pubmed: 2704740
PLoS Med. 2016 Oct 25;13(10):e1002153
pubmed: 27780206
Virology. 1969 Aug;38(4):666-78
pubmed: 5816954
Nature. 2000 Aug 24;406(6798):893-7
pubmed: 10972291
Nat Commun. 2012;3:1235
pubmed: 23212364
J Infect Dis. 2005 Nov 15;192(10):1686-93
pubmed: 16235165
PLoS Genet. 2017 Nov 28;13(11):e1007064
pubmed: 29182635
Cell. 2003 Jun 13;113(6):803-9
pubmed: 12809610
J Pathol. 2015 Jan;235(2):253-65
pubmed: 25294240
J Virol. 2012 Apr;86(7):3658-66
pubmed: 22278252
J Gen Virol. 2012 Mar;93(Pt 3):565-576
pubmed: 22170635
Nat Genet. 2017 May;49(5):666-673
pubmed: 28394351
Cell. 1988 Oct 21;55(2):255-65
pubmed: 3167982
Virology. 1983 Oct 15;130(1):44-55
pubmed: 6138898
J Virol. 2010 Mar;84(6):3033-42
pubmed: 20042501
J Virol. 2015 Aug;89(15):7735-47
pubmed: 25972541
Cell. 1989 Feb 10;56(3):331
pubmed: 2914324
PLoS Pathog. 2019 Feb 15;15(2):e1007605
pubmed: 30768648
Curr Opin Genet Dev. 1994 Dec;4(6):895-900
pubmed: 7888761
PLoS Pathog. 2018 Jun 28;14(6):e1007015
pubmed: 29953542
Virology. 2015 May;479-480:46-51
pubmed: 25824477
J Virol. 2018 Jul 31;92(16):
pubmed: 29848591
J Virol. 1999 May;73(5):4316-26
pubmed: 10196330
Curr Top Microbiol Immunol. 2009;330:55-72
pubmed: 19203104
Nature. 2003 Jul 3;424(6944):94-8
pubmed: 12808465
Biosci Trends. 2017 Sep 12;11(4):383-388
pubmed: 28717061
Virology. 1966 Jun;29(2):205-21
pubmed: 4287544
MMWR Morb Mortal Wkly Rep. 2017 Oct 27;66(42):1148-1153
pubmed: 29073125
Science. 2009 May 29;324(5931):1210-3
pubmed: 19478186
J Virol. 2011 Mar;85(5):2458-62
pubmed: 21159878
J Virol. 2006 Jun;80(12):6084-92
pubmed: 16731947
PLoS Biol. 2015 Sep 16;13(9):e1002251
pubmed: 26375597
J Virol. 2013 Jul;87(13):7200-9
pubmed: 23616660
PLoS Pathog. 2010 Jul 22;6(7):e1001005
pubmed: 20661479
Acta Med Scand. 1953;144(4):313-22
pubmed: 13039962
Proc Natl Acad Sci U S A. 2008 May 13;105(19):6970-5
pubmed: 18458341
J Virol. 2013 Mar;87(5):2526-34
pubmed: 23255790
EMBO J. 2002 May 15;21(10):2364-72
pubmed: 12006489
Clin Infect Dis. 1999 Feb;28(2):200-4
pubmed: 10064226
Nat Rev Mol Cell Biol. 2016 Feb;17(2):83-96
pubmed: 26648264
Science. 2006 Apr 21;312(5772):394-7
pubmed: 16627737
J Virol. 2013 Mar;87(5):2686-92
pubmed: 23255805
Curr Top Microbiol Immunol. 2009;329:59-76
pubmed: 19198562
Virology. 2015 May;479-480:131-45
pubmed: 25818029
J Infect Dis. 1994 Aug;170(2):443-8
pubmed: 8035034
J Virol. 1998 Feb;72(2):1224-34
pubmed: 9445022
J Virol. 2014 Jan;88(1):456-68
pubmed: 24155404
J Virol. 1999 Jan;73(1):51-4
pubmed: 9847306
Lancet Infect Dis. 2017 Dec;17(12):e420-e428
pubmed: 28757186
J Virol. 2017 May 12;91(11):
pubmed: 28331086
Virus Res. 2016 Jan 4;211:29-37
pubmed: 26428304
Virus Res. 1994 Mar;31(3):317-30
pubmed: 8191786
Curr Top Microbiol Immunol. 2016;392:303-22
pubmed: 26499340
Nature. 2011 Nov 02;480(7378):530-3
pubmed: 22048310
Front Microbiol. 2012 Jan 13;2:279
pubmed: 22347873
J Virol. 2002 Mar;76(5):2403-9
pubmed: 11836418
J Virol. 2015 Jul;89(14):7089-96
pubmed: 25926640