A blood-based signature of cerebrospinal fluid Aβ
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
11 03 2019
11 03 2019
Historique:
received:
17
04
2018
accepted:
03
12
2018
entrez:
12
3
2019
pubmed:
12
3
2019
medline:
25
9
2020
Statut:
epublish
Résumé
It is increasingly recognized that Alzheimer's disease (AD) exists before dementia is present and that shifts in amyloid beta occur long before clinical symptoms can be detected. Early detection of these molecular changes is a key aspect for the success of interventions aimed at slowing down rates of cognitive decline. Recent evidence indicates that of the two established methods for measuring amyloid, a decrease in cerebrospinal fluid (CSF) amyloid β
Identifiants
pubmed: 30853713
doi: 10.1038/s41598-018-37149-7
pii: 10.1038/s41598-018-37149-7
pmc: PMC6409361
doi:
Substances chimiques
Amyloid beta-Peptides
0
Apolipoproteins E
0
Biomarkers
0
Chemokine CCL26
0
Chromogranin A
0
Peptide Fragments
0
amyloid beta-protein (1-42)
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
4163Subventions
Organisme : NIA NIH HHS
ID : P30 AG010129
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG024904
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002369
Pays : United States
Investigateurs
Michael W Weiner
(MW)
Paul Aisen
(P)
Ronald Petersen
(R)
Clifford R Jack
(CR)
William Jagust
(W)
John Q Trojanowki
(JQ)
Arthur W Toga
(AW)
Laurel Beckett
(L)
Robert C Green
(RC)
Andrew J Saykin
(AJ)
John Morris
(J)
Leslie M Shaw
(LM)
Jeffrey Kaye
(J)
Joseph Quinn
(J)
Lisa Silbert
(L)
Betty Lind
(B)
Raina Carter
(R)
Sara Dolen
(S)
Lon S Schneider
(LS)
Sonia Pawluczyk
(S)
Mauricio Beccera
(M)
Liberty Teodoro
(L)
Bryan M Spann
(BM)
James Brewer
(J)
Helen Vanderswag
(H)
Adam Fleisher
(A)
Judith L Heidebrink
(JL)
Joanne L Lord
(JL)
Sara S Mason
(SS)
Colleen S Albers
(CS)
David Knopman
(D)
Kris Johnson
(K)
Rachelle S Doody
(RS)
Javier Villanueva-Meyer
(J)
Munir Chowdhury
(M)
Susan Rountree
(S)
Mimi Dang
(M)
Yaakov Stern
(Y)
Lawrence S Honig
(LS)
Karen L Bell
(KL)
Beau Ances
(B)
John C Morris
(JC)
Maria Carroll
(M)
Mary L Creech
(ML)
Erin Franklin
(E)
Mark A Mintun
(MA)
Stacy Schneider
(S)
Angela Oliver
(A)
Daniel Marson
(D)
Randall Griffth
(R)
David Clark
(D)
David Geldmacher
(D)
John Brockington
(J)
Erik Roberson
(E)
Marissa Natelson Love
(MN)
Hillel Grossman
(H)
Effie Mitsis
(E)
Raj C Shah
(RC)
Leyla deToledo-Morrell
(L)
Ranjan Duara
(R)
Daniel Varon
(D)
Maria T Greig
(MT)
Peggy Roberts
(P)
Marilyn Albert
(M)
Chiadi Onyike
(C)
Daniel D'Agostino
(D)
Stephanie Kielb
(S)
James E Galvin
(JE)
Brittany Cerbone
(B)
Christina A Michel
(CA)
Dana M Pogorelec
(DM)
Henry Rusinek
(H)
Mony J de Leon
(MJ)
Lidia Glodzik
(L)
Susan De Santi
(S)
P Murali Doraiswamy
(PM)
Jeffrey R Petrella
(JR)
Salvador Borges-Neto
(S)
Terence Z Wong
(TZ)
Edward Coleman
(E)
Charles D Smith
(CD)
Greg Jicha
(G)
Peter Hardy
(P)
Partha Sinha
(P)
Elizabeth Oates
(E)
Gary Conrad
(G)
Anton P Porsteinsson
(AP)
Bonnie S Goldstein
(BS)
Kim Martin
(K)
Kelly M Makino
(KM)
M Saleem Ismail
(MS)
Connie Brand
(C)
Ruth A Mulnard
(RA)
Gaby Thai
(G)
Catherine Mc-Adams-Ortiz
(C)
Kyle Womack
(K)
Dana Mathews
(D)
Mary Quiceno
(M)
Allan I Levey
(AI)
James J Lah
(JJ)
Janet S Cellar
(JS)
Jeffrey M Burns
(JM)
Russell H Swerdlow
(RH)
William M Brooks
(WM)
Liana Apostolova
(L)
Kathleen Tingus
(K)
Ellen Woo
(E)
Daniel H S Silverman
(DHS)
Po H Lu
(PH)
George Bartzokis
(G)
Neill R Graff-Radford
(NR)
Francine Parftt
(F)
Tracy Kendall
(T)
Heather Johnson
(H)
Martin R Farlow
(MR)
Ann Marie Hake
(AM)
Brandy R Matthews
(BR)
Jared R Brosch
(JR)
Scott Herring
(S)
Cynthia Hunt
(C)
Christopher H van Dyck
(CH)
Richard E Carson
(RE)
Martha G MacAvoy
(MG)
Pradeep Varma
(P)
Howard Chertkow
(H)
Howard Bergman
(H)
Chris Hosein
(C)
Sandra Black
(S)
Bojana Stefanovic
(B)
Curtis Caldwell
(C)
Ging-Yuek Robin Hsiung
(GR)
Howard Feldman
(H)
Benita Mudge
(B)
Michele Assaly
(M)
Elizabeth Finger
(E)
Stephen Pasternack
(S)
Irina Rachisky
(I)
Dick Trost
(D)
Andrew Kertesz
(A)
Charles Bernick
(C)
Donna Munic
(D)
Marek-Marsel Mesulam
(MM)
Kristine Lipowski
(K)
Sandra Weintraub
(S)
Borna Bonakdarpour
(B)
Diana Kerwin
(D)
Chuang-Kuo Wu
(CK)
Nancy Johnson
(N)
Carl Sadowsky
(C)
Teresa Villena
(T)
Raymond Scott Turner
(RS)
Kathleen Johnson
(K)
Brigid Reynolds
(B)
Reisa A Sperling
(RA)
Keith A Johnson
(KA)
Gad Marshall
(G)
Jerome Yesavage
(J)
Joy L Taylor
(JL)
Barton Lane
(B)
Allyson Rosen
(A)
Jared Tinklenberg
(J)
Marwan N Sabbagh
(MN)
Christine M Belden
(CM)
Sandra A Jacobson
(SA)
Sherye A Sirrel
(SA)
Neil Kowall
(N)
Ronald Killiany
(R)
Andrew E Budson
(AE)
Alexander Norbash
(A)
Patricia Lynn Johnson
(PL)
Thomas O Obisesan
(TO)
Saba Wolday
(S)
Joanne Allard
(J)
Alan Lerner
(A)
Paula Ogrocki
(P)
Curtis Tatsuoka
(C)
Parianne Fatica
(P)
Evan Fletcher
(E)
Pauline Maillard
(P)
John Olichney
(J)
Charles DeCarli
(C)
Owen Carmichael
(O)
Smita Kittur
(S)
Michael Borrie
(M)
T-Y Lee
(TY)
Rob Bartha
(R)
Sterling Johnson
(S)
Sanjay Asthana
(S)
Cynthia M Carlsson
(CM)
Steven G Potkin
(SG)
Adrian Preda
(A)
Dana Nguyen
(D)
Pierre Tariot
(P)
Anna Burke
(A)
Nadira Trncic
(N)
Adam Fleisher
(A)
Stephanie Reeder
(S)
Vernice Bates
(V)
Horacio Capote
(H)
Michelle Rainka
(M)
Douglas W Scharre
(DW)
Maria Kataki
(M)
Anahita Adeli
(A)
Earl A Zimmerman
(EA)
Dzintra Celmins
(D)
Alice D Brown
(AD)
Godfrey D Pearlson
(GD)
Karen Blank
(K)
Karen Anderson
(K)
Laura A Flashman
(LA)
Marc Seltzer
(M)
Mary L Hynes
(ML)
Robert B Santulli
(RB)
Kaycee M Sink
(KM)
Leslie Gordineer
(L)
Je D Williamson
(JD)
Pradeep Garg
(P)
Franklin Watkins
(F)
Brian R Ott
(BR)
Henry Querfurth
(H)
Geffrey Tremont
(G)
Stephen Salloway
(S)
Paul Malloy
(P)
Stephen Correia
(S)
Howard J Rosen
(HJ)
Bruce L Miller
(BL)
David Perry
(D)
Jacobo Mintzer
(J)
Kenneth Spicer
(K)
David Bachman
(D)
Nunzio Pomara
(N)
Raymundo Hernando
(R)
Antero Sarrael
(A)
Norman Relkin
(N)
Gloria Chaing
(G)
Michael Lin
(M)
Lisa Ravdin
(L)
Amanda Smith
(A)
Balebail Ashok Raj
(BA)
Kristin Fargher
(K)
Andrew Saykin
(A)
Kwangsik Nho
(K)
Mitchel Kling
(M)
John Toledo
(J)
Leslie Shaw
(L)
John Trojanowski
(J)
Lindsay Farrer
(L)
Gabi Kastsenmüller
(G)
Matthias Arnold
(M)
David Wishart
(D)
Peter Würtz
(P)
Sudeepa Bhattcharyya
(S)
Cornelia van Duijin
(C)
Lara Mangravite
(L)
Xianlin Han
(X)
Thomas Hankemeier
(T)
Oliver Fiehn
(O)
Dinesh Barupal
(D)
Ines Thiele
(I)
Almut Heinken
(A)
Peter Meikle
(P)
Nathan Price
(N)
Cory Funk
(C)
Wei Jia
(W)
Alexandra Kueider-Paisley
(A)
P Murali Doraiswamy
(PM)
Jessica Tenebaum
(J)
Colette Black
(C)
Arthur Moseley
(A)
Will Thompson
(W)
Siam Mahmoudiandehkorki
(S)
Rebecca Baillie
(R)
Kathleen Welsh-Bohmer
(K)
Brenda Plassman
(B)
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