Aged-senescent cells contribute to impaired heart regeneration.
aging
cardiac regeneration
cardiac repair
myocardial infarction
p16INK4a
progenitor cells
senescence
senescence-associated secretory phenotype
senolytics
Journal
Aging cell
ISSN: 1474-9726
Titre abrégé: Aging Cell
Pays: England
ID NLM: 101130839
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
19
10
2018
revised:
09
01
2019
accepted:
31
01
2019
pubmed:
12
3
2019
medline:
15
9
2020
entrez:
12
3
2019
Statut:
ppublish
Résumé
Aging leads to increased cellular senescence and is associated with decreased potency of tissue-specific stem/progenitor cells. Here, we have done an extensive analysis of cardiac progenitor cells (CPCs) isolated from human subjects with cardiovascular disease, aged 32-86 years. In aged subjects (>70 years old), over half of CPCs are senescent (p16
Identifiants
pubmed: 30854802
doi: 10.1111/acel.12931
pmc: PMC6516154
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12931Subventions
Organisme : Robert J. and Theresa W. Ryan
Pays : International
Organisme : NIA NIH HHS
ID : R37 AG013925
Pays : United States
Organisme : Noaber Foundation
Pays : International
Organisme : British Heart Foundation
ID : PG/14/11/30657
Pays : United Kingdom
Organisme : Glenn/American Federation for Aging Research (AFAR) BIG Award
Pays : International
Organisme : Medical Research Council
ID : MR/P026508/1
Pays : United Kingdom
Organisme : Italian Ministry of Health
ID : GR-2010-2318945
Pays : International
Organisme : NIA NIH HHS
ID : R01 AG013925
Pays : United States
Organisme : Robert and Arlene Kogod
Pays : International
Organisme : The Connor group
Pays : International
Informations de copyright
© 2019 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.
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