Postnatally Acquired Zika Virus Disease Among Children, United States, 2016-2017.
Zika
epidemiology
pediatric
Journal
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
ISSN: 1537-6591
Titre abrégé: Clin Infect Dis
Pays: United States
ID NLM: 9203213
Informations de publication
Date de publication:
02 01 2020
02 01 2020
Historique:
received:
17
12
2018
accepted:
01
03
2019
pubmed:
12
3
2019
medline:
7
1
2021
entrez:
12
3
2019
Statut:
ppublish
Résumé
The clinical findings among children with postnatally acquired Zika virus disease are not well characterized. We describe and compare clinical signs and symptoms for children aged <18 years. Zika virus disease cases were included if they met the national surveillance case definition, had illness onset in 2016 or 2017, resided in a participating state, and were reported to the Centers for Disease Control and Prevention. Pediatric cases were aged <18 years; congenital and perinatal infections were excluded. Pediatric cases were matched to adult cases (18‒49 years). Clinical information was compared between younger and older pediatric cases and between children and adults. A total of 141 pediatric Zika virus disease cases were identified; none experienced neurologic disease. Overall, 28 (20%) were treated in an emergency department, 1 (<1%) was hospitalized; none died. Of the 4 primary clinical signs and symptoms associated with Zika virus disease, 133 (94%) children had rash, 104 (74%) fever, 67 (48%) arthralgia, and 51 (36%) conjunctivitis. Fever, arthralgia, and myalgia were more common in older children (12‒17 years) than younger children (1‒11 years). Arthralgia, arthritis, edema, and myalgia were more common in adults compared to children. This report supports previous findings that Zika virus disease is generally mild in children. The most common symptoms are similar to other childhood infections, and clinical findings and outcomes are similar to those in adults. Healthcare providers should consider a diagnosis of Zika virus infection in children with fever, rash, arthralgia, or conjunctivitis, who reside in or have traveled to an area where Zika virus transmission is occurring.
Sections du résumé
BACKGROUND
The clinical findings among children with postnatally acquired Zika virus disease are not well characterized. We describe and compare clinical signs and symptoms for children aged <18 years.
METHODS
Zika virus disease cases were included if they met the national surveillance case definition, had illness onset in 2016 or 2017, resided in a participating state, and were reported to the Centers for Disease Control and Prevention. Pediatric cases were aged <18 years; congenital and perinatal infections were excluded. Pediatric cases were matched to adult cases (18‒49 years). Clinical information was compared between younger and older pediatric cases and between children and adults.
RESULTS
A total of 141 pediatric Zika virus disease cases were identified; none experienced neurologic disease. Overall, 28 (20%) were treated in an emergency department, 1 (<1%) was hospitalized; none died. Of the 4 primary clinical signs and symptoms associated with Zika virus disease, 133 (94%) children had rash, 104 (74%) fever, 67 (48%) arthralgia, and 51 (36%) conjunctivitis. Fever, arthralgia, and myalgia were more common in older children (12‒17 years) than younger children (1‒11 years). Arthralgia, arthritis, edema, and myalgia were more common in adults compared to children.
CONCLUSIONS
This report supports previous findings that Zika virus disease is generally mild in children. The most common symptoms are similar to other childhood infections, and clinical findings and outcomes are similar to those in adults. Healthcare providers should consider a diagnosis of Zika virus infection in children with fever, rash, arthralgia, or conjunctivitis, who reside in or have traveled to an area where Zika virus transmission is occurring.
Identifiants
pubmed: 30855072
pii: 5373555
doi: 10.1093/cid/ciz195
pmc: PMC7135923
mid: NIHMS1565205
doi:
Types de publication
Journal Article
Research Support, U.S. Gov't, P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
227-231Subventions
Organisme : Intramural CDC HHS
ID : CC999999
Pays : United States
Investigateurs
Wendy Jilek
(W)
Jennifer Brown
(J)
Taryn Stevens
(T)
Julius Tonzel
(J)
Christine Scott-Waldron
(C)
Sean Simonson
(S)
Katherine Feldman
(K)
Richard Brooks
(R)
Megan Galvin
(M)
Sarah Scotland
(S)
Catherine Brown
(C)
Kristin Garafalo
(K)
Mojisola Ojo
(M)
Karen Worthington
(K)
Nadia Thomas
(N)
Erica Jamro
(E)
Jonah Long
(J)
Barry Miller
(B)
Sepehr Arshadmansab
(S)
Kelly Broussard
(K)
Nicole Evert
(N)
Jim Broyhill
(J)
Elena Mircoff
(E)
Informations de copyright
Published by Oxford University Press for the Infectious Diseases Society of America 2019.
Références
J Biomed Inform. 2009 Apr;42(2):377-81
pubmed: 18929686
JAMA Pediatr. 2018 Jul 1;172(7):686-693
pubmed: 29813148
N Engl J Med. 2009 Jun 11;360(24):2536-43
pubmed: 19516034
Pediatrics. 2017 Dec;140(6):
pubmed: 29093135
Clin Infect Dis. 2016 Nov 1;63(9):1198-1201
pubmed: 27418575
Lancet. 2016 Apr 9;387(10027):1531-1539
pubmed: 26948433
Pediatrics. 2016 May;137(5):
pubmed: 27009036
Pediatr Rep. 2018 Jan 03;9(4):7341
pubmed: 29383222
Am J Trop Med Hyg. 1969 Nov;18(6):954-71
pubmed: 5355242
Clin Infect Dis. 2019 Mar 5;68(6):919-926
pubmed: 30184178
Paediatr Perinat Epidemiol. 2017 Nov;31(6):537-545
pubmed: 28806479
MMWR Morb Mortal Wkly Rep. 2016 Oct 07;65(39):1082-1085
pubmed: 27711041
Pediatr Infect Dis J. 2012 May;31(5):459-63
pubmed: 22301475
Neurocrit Care. 2017 Jun;26(3):457-463
pubmed: 27995511
Clin Infect Dis. 2017 May 15;64(10):1445-1448
pubmed: 28186536