The Macromolecular Femtosecond Crystallography Instrument at the Linac Coherent Light Source.
X-ray FEL
X-ray free-electron laser
protein crystallography
room-temperature crystallography
serial femtosecond crystallography
time-resolved crystallography
Journal
Journal of synchrotron radiation
ISSN: 1600-5775
Titre abrégé: J Synchrotron Radiat
Pays: United States
ID NLM: 9888878
Informations de publication
Date de publication:
01 Mar 2019
01 Mar 2019
Historique:
received:
22
10
2018
accepted:
28
01
2019
entrez:
12
3
2019
pubmed:
12
3
2019
medline:
12
3
2019
Statut:
ppublish
Résumé
The Macromolecular Femtosecond Crystallography (MFX) instrument at the Linac Coherent Light Source (LCLS) is the seventh and newest instrument at the world's first hard X-ray free-electron laser. It was designed with a primary focus on structural biology, employing the ultrafast pulses of X-rays from LCLS at atmospheric conditions to overcome radiation damage limitations in biological measurements. It is also capable of performing various time-resolved measurements. The MFX design consists of a versatile base system capable of supporting multiple methods, techniques and experimental endstations. The primary techniques supported are forward scattering and crystallography, with capabilities for various spectroscopic methods and time-resolved measurements. The location of the MFX instrument allows for utilization of multiplexing methods, increasing user access to LCLS by running multiple experiments simultaneously.
Identifiants
pubmed: 30855242
pii: S1600577519001577
doi: 10.1107/S1600577519001577
pmc: PMC6412173
doi:
Types de publication
Journal Article
Langues
eng
Pagination
346-357Subventions
Organisme : Basic Energy Sciences
ID : DE-AC02-76SF00515
Informations de copyright
open access.
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