High-Relaxivity Gd(III)-Hemicryptophane Complex.
Journal
Organic letters
ISSN: 1523-7052
Titre abrégé: Org Lett
Pays: United States
ID NLM: 100890393
Informations de publication
Date de publication:
05 04 2019
05 04 2019
Historique:
pubmed:
12
3
2019
medline:
12
3
2019
entrez:
12
3
2019
Statut:
ppublish
Résumé
The polytopic hemicryptophane cage HC1 combining a cyclotriveratrylene (CTV) unit and a tris(2-aminoethyl)amine (tren) moiety connected by three 2-hydroxyisophthalamide linkers was synthesized in 12 steps. The resulting highly functionalized covalent host is soluble in aqueous medium and has been used to complex Gd(III) ion. The Gd(III)@HC1 complex presents promising relaxivity properties when compared to the clinically used Dotarem MRI agent.
Identifiants
pubmed: 30855968
doi: 10.1021/acs.orglett.9b00081
doi:
Types de publication
Journal Article
Langues
eng