CBP/p300 in brain development and plasticity: disentangling the KAT's cradle.

Acetylation Animals Brain p300-CBP Transcription Factors

Journal

Current opinion in neurobiology
ISSN: 1873-6882
Titre abrégé: Curr Opin Neurobiol
Pays: England
ID NLM: 9111376

Informations de publication

Date de publication:
12 2019
Historique:
received: 28 11 2018
accepted: 30 01 2019
pubmed: 12 3 2019
medline: 19 2 2020
entrez: 12 3 2019
Statut: ppublish

Résumé

The paralogous transcriptional co-activators CBP and p300 (aka KAT3A and KAT3B, respectively) contain a characteristic and promiscuous lysine acetyltransferase (KAT) domain and multiple independent protein-binding domains that enable them to interact with hundreds of proteins, possibly promoting the acetylation of thousands of target lysine residues. Both proteins play critical roles during the development of the nervous system and may also regulate stimuli-driven transcription and plasticity in postmitotic neurons. The multiplicity of functions, substrates, and molecular partners, together with the redundancy and singularity of the two KAT3 paralogs, define a complex cat's cradle of relationships. In this review, we discuss the role of the KAT3 proteins in neurons and integrate recent information regarding their function and mode of action.

Identifiants

DOI: 10.1016/j.conb.2019.01.023 PMID: 30856481
pubmed: 30856481
pii: S0959-4388(18)30210-1
doi: 10.1016/j.conb.2019.01.023
pii:
doi:

Substances chimiques

p300-CBP Transcription Factors EC 2.3.1.48

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

1-8

Informations de copyright

Copyright © 2019 Elsevier Ltd. All rights reserved.

Auteurs

Michal Lipinski (M)

Instituto de Neurociencias (Universidad Miguel Hernández - Consejo Superior de Investigaciones Científicas), Av. Santiago Ramón y Cajal s/n, Sant Joan d'Alacant, 03550, Alicante, Spain.

Beatriz Del Blanco (B)

Instituto de Neurociencias (Universidad Miguel Hernández - Consejo Superior de Investigaciones Científicas), Av. Santiago Ramón y Cajal s/n, Sant Joan d'Alacant, 03550, Alicante, Spain.

Angel Barco (A)

Instituto de Neurociencias (Universidad Miguel Hernández - Consejo Superior de Investigaciones Científicas), Av. Santiago Ramón y Cajal s/n, Sant Joan d'Alacant, 03550, Alicante, Spain. Electronic address: abarco@umh.es.

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Classifications MeSH

questionsmedicales.fr › Métabolisme › Acylation › Acétylation › CBP/p300 in brain development and plasticity:...
questionsmedicales.fr › Eucaryotes › Animaux › CBP/p300 in brain development and plasticity:...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › CBP/p300 in brain development and plasticity:...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription CBP-p300 › CBP/p300 in brain development and plasticity:...