Claudin-1 inhibits human parainfluenza virus type 2 dissemination.
Cell-to-cell spread
Claudin-1
Human parainfluenza virus type 2
Tight junctions
V protein
Journal
Virology
ISSN: 1096-0341
Titre abrégé: Virology
Pays: United States
ID NLM: 0110674
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
09
10
2018
revised:
04
01
2019
accepted:
22
01
2019
pubmed:
12
3
2019
medline:
23
10
2019
entrez:
12
3
2019
Statut:
ppublish
Résumé
Tight junctions enable epithelial cells to form physical barriers that act as an innate immune defense against respiratory infection. However, the involvement of tight junction molecules in paramyxovirus infections, which include various respiratory pathogens, has not been examined in detail. Human parainfluenza virus type 2 (hPIV2) infects airway epithelial cells and causes respiratory illness. In the present study, we found that hPIV2 infection of cultured cells induces expression of claudin-1 (CLDN1), an essential component of tight junctions. This induction seemed to be intrinsically restricted by V, an accessory protein that modulates various host responses, to enable efficient virus propagation. By generating CLDN1 over-expressing and knockout cell lines, we showed that CLDN1 is involved in the restriction of hPIV2 spread via cell-to-cell contact. Taken together, we identified CLDN1 an inhibitory factor for hPIV2 dissemination, and that its V protein acts to counter this.
Identifiants
pubmed: 30856486
pii: S0042-6822(19)30025-X
doi: 10.1016/j.virol.2019.01.031
pii:
doi:
Substances chimiques
Claudin-1
0
Viral Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
93-99Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.