Thyronamine regulation of TAAR1 expression in breast cancer cells and investigation of its influence on viability and migration.
3-iodothyronamine
MCF7
T47D
TAAR1
Tetrac
breast cancer
Journal
Breast cancer (Dove Medical Press)
ISSN: 1179-1314
Titre abrégé: Breast Cancer (Dove Med Press)
Pays: New Zealand
ID NLM: 101591856
Informations de publication
Date de publication:
2019
2019
Historique:
entrez:
13
3
2019
pubmed:
13
3
2019
medline:
13
3
2019
Statut:
epublish
Résumé
A correlation exists between breast cancer and thyroid disorders, which are common in elderly women. Thyroid hormones are degraded into trace amines, which can bind to the G-protein-coupled receptor trace amine-associated receptor 1 (TAAR1) and thereby activate it. The transformation of thyroid hormones into trace amines is carried out by the ornithine decarboxylase. Previously, we showed that TAAR1 overexpression (IRS ≥6) was associated with a significantly longer OS in primary breast cancer patients during a long-term follow-up of up to 14 years. Aim of the present study was to analyze the regulation of TAAR1 in breast cancer cell lines and the influence of triiodothyronine (T The effect of T Stimulation of MCF-7 cells with 10 nM 3-iodothyronamine (T A significant upregulation of TAAR1 induced by stimulation with T
Identifiants
pubmed: 30858725
doi: 10.2147/BCTT.S178721
pii: bctt-11-087
pmc: PMC6385785
doi:
Types de publication
Journal Article
Langues
eng
Pagination
87-97Déclaration de conflit d'intérêts
Disclosure The authors report no conflicts of interest in this work.
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