Differences in
Acute myeloid leukemia
Anthracycline
Daunorubicin
Idarubicin
Mitoxantrone
Personalized medicine
ex-vivo test
Journal
Mediterranean journal of hematology and infectious diseases
ISSN: 2035-3006
Titre abrégé: Mediterr J Hematol Infect Dis
Pays: Italy
ID NLM: 101530512
Informations de publication
Date de publication:
2019
2019
Historique:
received:
10
10
2018
accepted:
12
01
2019
entrez:
13
3
2019
pubmed:
13
3
2019
medline:
13
3
2019
Statut:
epublish
Résumé
Induction schedules in acute myeloid leukemia (AML) are based on combinations of cytarabine and anthracyclines. The choice of the anthracycline employed has been widely studied in multiple clinical trials showing similar complete remission rates. Using an Similar dose-respond graphs were generated for the three anthracyclines, with a slight decrease in EC A third of the patients could benefit from the use of this test in the first line induction therapy selection, although it should be confirmed in a clinical trial specifically designed.
Sections du résumé
BACKGROUND
BACKGROUND
Induction schedules in acute myeloid leukemia (AML) are based on combinations of cytarabine and anthracyclines. The choice of the anthracycline employed has been widely studied in multiple clinical trials showing similar complete remission rates.
MATERIALS AND METHODS
METHODS
Using an
RESULTS
RESULTS
Similar dose-respond graphs were generated for the three anthracyclines, with a slight decrease in EC
DISCUSSION
CONCLUSIONS
A third of the patients could benefit from the use of this test in the first line induction therapy selection, although it should be confirmed in a clinical trial specifically designed.
Identifiants
pubmed: 30858954
doi: 10.4084/MJHID.2019.016
pii: mjhid-11-1-e2019016
pmc: PMC6402555
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e2019016Déclaration de conflit d'intérêts
Competing interests: The authors have declared that no competing interests exist.
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