Regulatory T and B cells in peripheral blood of subcutaneous immunotherapy-treated Japanese cedar pollinosis patients.
Adult
Aged
Aged, 80 and over
Allergens
/ immunology
Antigens, Plant
/ immunology
B-Lymphocytes, Regulatory
/ immunology
Basic-Leucine Zipper Transcription Factors
/ genetics
Biomarkers
/ metabolism
Blood Circulation
Cryptomeria
/ immunology
Desensitization, Immunologic
/ methods
Female
Humans
Injections, Subcutaneous
Interleukin-10
/ genetics
Male
Middle Aged
Pollen
/ immunology
Rhinitis, Allergic, Seasonal
/ immunology
T-Lymphocytes, Regulatory
/ immunology
Young Adult
allergies
cellular immunology
clinical immunology
immunological markers
immunotherapy
Journal
Immunotherapy
ISSN: 1750-7448
Titre abrégé: Immunotherapy
Pays: England
ID NLM: 101485158
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
entrez:
13
3
2019
pubmed:
13
3
2019
medline:
7
3
2020
Statut:
ppublish
Résumé
The aim of this study was to clarify whether there are more regulatory T (Treg) and regulatory B (Breg) cells, and higher levels of IL-10-related transcription factors in subcutaneous immunotherapy (SCIT)-treated pollinosis patients than in non-SCIT-treated patients. Japanese cedar pollinosis patients undergoing SCIT had received treatment for at least 2.8 years. Peripheral blood mononuclear cells were used for flow cytometer analyses and mRNA measurement. The numbers of type 1 regulatory T (Tr1)-like cells and Breg cells, and expression of E4BP4 mRNA by peripheral blood mononuclear cells in SCIT-treated patients were higher than those in non-SCIT-treated patients. Tr1-like cells, Breg cells and E4BP4 may be involved in the effectiveness of SCIT.
Identifiants
pubmed: 30860439
doi: 10.2217/imt-2018-0170
doi:
Substances chimiques
Allergens
0
Antigens, Plant
0
Basic-Leucine Zipper Transcription Factors
0
Biomarkers
0
NFIL3 protein, human
0
Interleukin-10
130068-27-8
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM