ROCK inhibition improves axonal regeneration in a preclinical model of amyotrophic lateral sclerosis.

Amides / pharmacology Amyotrophic Lateral Sclerosis / drug therapy Animals Axons / drug effects Disease Models, Animal Enzyme Inhibitors / pharmacology Female Male Mice Mice, Transgenic Nerve Regeneration / drug effects Pyridines / pharmacology Sciatic Neuropathy / drug therapy Superoxide Dismutase / genetics rho-Associated Kinases / antagonists & inhibitors
RRID:IMSR_JAX:002726 Y-27632 amyotrophic lateral sclerosis axonal regeneration rho kinase

Journal

The Journal of comparative neurology
ISSN: 1096-9861
Titre abrégé: J Comp Neurol
Pays: United States
ID NLM: 0406041

Informations de publication

Date de publication:
01 10 2019
Historique:
received: 11 07 2018
revised: 11 02 2019
accepted: 12 02 2019
pubmed: 13 3 2019
medline: 6 10 2020
entrez: 13 3 2019
Statut: ppublish

Résumé

Alteration of the RhoA/ROCK (Rho kinase) pathway has been shown to be neuroprotective in SOD1

Identifiants

DOI: 10.1002/cne.24679 PMID: 30861116
pubmed: 30861116
doi: 10.1002/cne.24679
doi:

Substances chimiques

Amides 0
Enzyme Inhibitors 0
Pyridines 0
Y 27632 138381-45-0
SOD1 G93A protein EC 1.15.1.1
Superoxide Dismutase EC 1.15.1.1
rho-Associated Kinases EC 2.7.11.1

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

2334-2340

Informations de copyright

© 2019 Wiley Periodicals, Inc.

Auteurs

Abhijeet R Joshi (AR)

Department of Neurology, University Hospital of Cologne, Cologne, Germany.
Center for Molecular Medicine Cologne, University of Cologne, Germany.

Ines Muke (I)

Department of Neurology, University Hospital of Cologne, Cologne, Germany.
Center for Molecular Medicine Cologne, University of Cologne, Germany.

Ilja Bobylev (I)

Department of Neurology, University Hospital of Cologne, Cologne, Germany.
Center for Molecular Medicine Cologne, University of Cologne, Germany.

Helmar C Lehmann (HC)

Department of Neurology, University Hospital of Cologne, Cologne, Germany.
Center for Molecular Medicine Cologne, University of Cologne, Germany.
ORCID: 0000-0003-0674-9891

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Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Amides › ROCK inhibition improves axonal regeneration...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Troubles de l'homéostasie des protéines › Protéinopathies TDP-43 › Sclérose latérale amyotrophique › ROCK inhibition improves axonal regeneration...
questionsmedicales.fr › Eucaryotes › Animaux › ROCK inhibition improves axonal regeneration...
questionsmedicales.fr › Cellules › Neurones › Neurofibres › Axones › ROCK inhibition improves axonal regeneration...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › ROCK inhibition improves axonal regeneration...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › ROCK inhibition improves axonal regeneration...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › ROCK inhibition improves axonal regeneration...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › ROCK inhibition improves axonal regeneration...
questionsmedicales.fr › Phénomènes biologiques › Régénération › Régénération nerveuse › ROCK inhibition improves axonal regeneration...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyridines › ROCK inhibition improves axonal regeneration...
questionsmedicales.fr › Maladies du système nerveux › Maladies neuromusculaires › Neuropathies périphériques › Mononeuropathies › Neuropathie du nerf sciatique › ROCK inhibition improves axonal regeneration...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Superoxide dismutase › ROCK inhibition improves axonal regeneration...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › rho-Associated Kinases › ROCK inhibition improves axonal regeneration...