Circular RNAs in Cancer.
biogenesis
biological functions
cancer biomarkers
circular RNAs
exosomes
hallmarks of cancer
hematological malignancies
malignant tumors
oncogenic function
platelets
Journal
Molecular therapy. Nucleic acids
ISSN: 2162-2531
Titre abrégé: Mol Ther Nucleic Acids
Pays: United States
ID NLM: 101581621
Informations de publication
Date de publication:
07 Jun 2019
07 Jun 2019
Historique:
received:
09
10
2018
revised:
11
02
2019
accepted:
11
02
2019
pubmed:
13
3
2019
medline:
13
3
2019
entrez:
13
3
2019
Statut:
ppublish
Résumé
Circular RNAs (circRNAs) are a class of single-stranded closed RNA molecules that are formed by precursor mRNA back-splicing or skipping events of thousands of genes in eukaryotes as covalently closed continuous loops. High-throughput sequencing and bioinformatics approaches have uncovered the broad expression of circRNAs across species. Their high stability, abundance, and evolutionary conservation among species points to their distinct properties and diverse cellular functions as efficient microRNAs and protein sponges; they also play important roles in modulating transcription and splicing. Additionally, most circRNAs are aberrantly expressed in pathological conditions and in a tissue-specific manner such as development and progression of cancer. Herein, we highlight the characteristics, functions, and mechanisms of action of circRNAs in cancer; we also provide an overview of recent progress in the circRNA field and future application of circRNAs as cancer biomarkers and novel therapeutic targets.
Identifiants
pubmed: 30861414
pii: S2162-2531(19)30035-6
doi: 10.1016/j.omtn.2019.02.005
pmc: PMC6411617
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
118-129Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.
Références
Cell. 2011 Mar 4;144(5):646-74
pubmed: 21376230
PLoS One. 2012;7(2):e30733
pubmed: 22319583
RNA. 2013 Feb;19(2):141-57
pubmed: 23249747
Nature. 2013 Mar 21;495(7441):384-8
pubmed: 23446346
Nature. 2013 Mar 21;495(7441):333-8
pubmed: 23446348
Cancer Res. 2013 Sep 15;73(18):5609-12
pubmed: 24014594
Mol Cell. 2013 Sep 26;51(6):792-806
pubmed: 24035497
Genome Biol. 2014 Jul 29;15(7):409
pubmed: 25070500
Mol Cell. 2014 Oct 2;56(1):55-66
pubmed: 25242144
Genome Res. 2014 Nov;24(11):1774-86
pubmed: 25258385
Clin Chem. 2015 Jan;61(1):221-30
pubmed: 25376581
Nat Struct Mol Biol. 2015 Mar;22(3):256-64
pubmed: 25664725
RNA Biol. 2015;12(4):381-8
pubmed: 25746834
Oncotarget. 2015 Mar 20;6(8):6001-13
pubmed: 25749389
Front Immunol. 2015 Feb 20;6:70
pubmed: 25750642
PLoS One. 2015 Jun 25;10(6):e0131225
pubmed: 26110611
Cell Res. 2015 Aug;25(8):981-4
pubmed: 26138677
Circ Res. 2015 Oct 23;117(10):884-90
pubmed: 26377962
Nucleic Acids Res. 2016 Feb 18;44(3):e29
pubmed: 26442529
PLoS One. 2015 Oct 20;10(10):e0141214
pubmed: 26485708
Cancer Biomark. 2016;16(1):161-9
pubmed: 26600397
Mar Drugs. 2015 Nov 19;13(11):6962-76
pubmed: 26610526
Oncogene. 2016 Jul 28;35(30):3919-31
pubmed: 26657152
Blood. 2016 Mar 3;127(9):e1-e11
pubmed: 26660425
J Cell Biol. 2016 Jan 4;212(1):13-27
pubmed: 26728853
Oncotarget. 2016 Mar 1;7(9):9951-63
pubmed: 26848861
Nucleic Acids Res. 2016 Apr 7;44(6):2846-58
pubmed: 26861625
Nat Rev Mol Cell Biol. 2016 Apr;17(4):205-11
pubmed: 26908011
Cell. 2016 Apr 7;165(2):289-302
pubmed: 27040497
Oncotarget. 2016 May 3;7(18):26680-91
pubmed: 27058418
Nat Rev Cancer. 2016 Apr 26;16(5):273
pubmed: 27112204
Clin Chem Lab Med. 2016 Dec 1;54(12):1871-1879
pubmed: 27166723
Genome Res. 2016 Sep;26(9):1277-87
pubmed: 27365365
Sci Rep. 2016 Aug 03;6:30919
pubmed: 27484176
Sci Rep. 2016 Aug 11;6:31313
pubmed: 27510448
J Cancer Res Clin Oncol. 2017 Jan;143(1):17-27
pubmed: 27614453
Biomed Res Int. 2016;2016:1579490
pubmed: 27642589
Nat Rev Genet. 2016 Oct 14;17(11):679-692
pubmed: 27739534
Blood Cancer J. 2016 Oct 14;6(10):e483
pubmed: 27740630
Postgrad Med J. 2017 Mar;93(1097):153-158
pubmed: 27852946
Cell Death Differ. 2017 Feb;24(2):357-370
pubmed: 27886165
Sci Rep. 2016 Nov 28;6:37982
pubmed: 27892494
Nucleic Acids Res. 2017 Apr 20;45(7):4021-4035
pubmed: 27928058
Cancer Lett. 2017 Mar 1;388:208-219
pubmed: 27986464
Onco Targets Ther. 2016 Dec 09;9:7451-7458
pubmed: 28003761
Yale J Biol Med. 2016 Dec 23;89(4):527-537
pubmed: 28018143
Sci Rep. 2017 Jan 03;7:39918
pubmed: 28045102
J Hematol Oncol. 2017 Jan 3;10(1):2
pubmed: 28049499
Br J Cancer. 2017 Feb 28;116(5):626-633
pubmed: 28081541
Crit Rev Biochem Mol Biol. 2017 Apr;52(2):220-233
pubmed: 28095716
Circ Res. 2017 Jan 20;120(2):418-435
pubmed: 28104774
Dis Markers. 2017;2017:4587698
pubmed: 28167847
Mol Oncol. 2017 Apr;11(4):422-437
pubmed: 28211215
J Hematol Oncol. 2017 Feb 20;10(1):52
pubmed: 28219405
Int J Cancer. 2017 Jul 15;141(2):220-230
pubmed: 28240776
Cancer Res. 2017 May 1;77(9):2339-2350
pubmed: 28249903
Int J Mol Sci. 2017 Mar 09;18(3):
pubmed: 28282919
Pathol Res Pract. 2017 May;213(5):453-456
pubmed: 28343871
Mol Cell. 2017 Apr 6;66(1):9-21.e7
pubmed: 28344080
Oncotarget. 2017 Apr 11;8(15):25571-25581
pubmed: 28424426
Bioorg Med Chem. 2017 Jul 1;25(13):3396-3405
pubmed: 28478865
Hepatology. 2017 Oct;66(4):1151-1164
pubmed: 28520103
J Clin Lab Anal. 2018 Mar;32(3):null
pubmed: 28618205
Mol Ther. 2017 Sep 6;25(9):2062-2074
pubmed: 28676341
FEBS J. 2017 Jul;284(14):2170-2182
pubmed: 28685964
Cancer Lett. 2017 Sep 10;403:305-317
pubmed: 28687357
Tumour Biol. 2017 Jul;39(7):1010428317719577
pubmed: 28695771
Stroke. 2017 Sep;48(9):2541-2548
pubmed: 28701578
Cancer Lett. 2017 Sep 28;404:8-18
pubmed: 28705773
Cell Biol Int. 2017 Sep;41(9):1056-1064
pubmed: 28707774
Sci Rep. 2017 Jul 14;7(1):5428
pubmed: 28710406
Biomed Res Int. 2017;2017:5936171
pubmed: 28717649
Anticancer Res. 2017 Aug;37(8):4337-4343
pubmed: 28739726
Am J Cancer Res. 2017 Jul 01;7(7):1566-1576
pubmed: 28744405
EMBO Rep. 2017 Sep;18(9):1646-1659
pubmed: 28794202
Theranostics. 2017 Jul 22;7(12):3106-3117
pubmed: 28839467
J Natl Cancer Inst. 2018 Mar 1;110(3):
pubmed: 28903484
DNA Cell Biol. 2017 Nov;36(11):901-908
pubmed: 28933584
Oncotarget. 2017 Apr 6;8(35):58405-58416
pubmed: 28938566
Biomed Pharmacother. 2017 Nov;95:1514-1519
pubmed: 28946214
World J Gastroenterol. 2017 Sep 14;23(34):6330-6338
pubmed: 28974900
Cell Cycle. 2017;16(23):2301-2311
pubmed: 28980874
Oncogene. 2018 Feb 1;37(5):555-565
pubmed: 28991235
J Exp Clin Cancer Res. 2017 Oct 16;36(1):145
pubmed: 29037220
J Exp Clin Cancer Res. 2017 Nov 2;36(1):152
pubmed: 29096676
Cancer Biomark. 2018 Feb 6;21(2):299-306
pubmed: 29103021
Biochem Biophys Res Commun. 2018 Jan 1;495(1):189-196
pubmed: 29117539
Theranostics. 2017 Sep 26;7(17):4183-4191
pubmed: 29158818
Cancer Lett. 2018 Feb 1;414:301-309
pubmed: 29174799
Oncotarget. 2017 Oct 10;8(53):91674-91683
pubmed: 29207676
Biomed Pharmacother. 2017 Dec;96:892-898
pubmed: 29223555
Biochem Biophys Res Commun. 2018 Jan 15;495(3):2369-2375
pubmed: 29229385
Mol Ther Oncolytics. 2017 Oct 24;8:1-13
pubmed: 29234727
EBioMedicine. 2018 Jan;27:18-26
pubmed: 29248507
Int J Mol Med. 2018 Feb;41(2):946-954
pubmed: 29251325
NPJ Genom Med. 2017 Nov 28;2:36
pubmed: 29263845
J Huazhong Univ Sci Technolog Med Sci. 2017 Dec;37(6):886-890
pubmed: 29270748
Oncol Rep. 2018 Mar;39(3):951-966
pubmed: 29286141
Biochem Biophys Res Commun. 2018 Feb 5;496(2):455-461
pubmed: 29337065
J Extracell Vesicles. 2018 Jan 15;7(1):1424473
pubmed: 29359036
J Cancer Res Clin Oncol. 2018 Apr;144(4):667-674
pubmed: 29372377
J Hepatol. 2018 Jun;68(6):1214-1227
pubmed: 29378234
Mol Cancer. 2018 Jan 31;17(1):19
pubmed: 29386015
Front Immunol. 2018 Jan 22;9:9
pubmed: 29403493
Pharmacol Ther. 2018 Jul;187:31-44
pubmed: 29406246
Cancer Lett. 2018 Apr 10;419:152-166
pubmed: 29414303
Sci Rep. 2018 Feb 13;8(1):2878
pubmed: 29440731
Am J Transl Res. 2018 Feb 15;10(2):592-604
pubmed: 29511454
Biochem Biophys Res Commun. 2018 Apr 15;498(4):1009-1015
pubmed: 29550475
Int J Biol Sci. 2018 Feb 12;14(3):321-330
pubmed: 29559849
Biomed Pharmacother. 2018 Feb;98:775-782
pubmed: 29571246
Cancer Res. 2018 Jun 1;78(11):2839-2851
pubmed: 29588350
Cancer Manag Res. 2018 Mar 19;10:535-544
pubmed: 29593432
Biomed Pharmacother. 2018 Jun;102:639-644
pubmed: 29602132
Biochem Biophys Res Commun. 2018 May 23;499(4):1044-1049
pubmed: 29608893
Mol Med Rep. 2018 Jun;17(6):7692-7700
pubmed: 29620202
Cancer Cell. 2018 Jun 11;33(6):965-983
pubmed: 29657130
Biochem Biophys Res Commun. 2018 Jun 22;501(2):428-433
pubmed: 29738762
Mol Ther Nucleic Acids. 2018 Jun 1;11:455-467
pubmed: 29858080
Eur Rev Med Pharmacol Sci. 2018 Jun;22(12):3713-3718
pubmed: 29949144
Curr Med Chem. 2018 Jul 26;:null
pubmed: 30047325
Mol Ther Nucleic Acids. 2018 Sep 7;12:817-828
pubmed: 30153566
Dig Dis Sci. 2019 Jan;64(1):113-122
pubmed: 30259280
Int J Mol Sci. 2018 Oct 22;19(10):null
pubmed: 30360388