Antidepressant Use Among People Prescribed Opioids for Chronic Noncancer Pain.
Aged
Analgesics, Non-Narcotic
/ therapeutic use
Analgesics, Opioid
/ therapeutic use
Anticonvulsants
/ therapeutic use
Antidepressive Agents
/ therapeutic use
Antipsychotic Agents
/ therapeutic use
Benzodiazepines
/ therapeutic use
Chronic Pain
/ complications
Cohort Studies
Depressive Disorder
/ complications
Female
Humans
Male
Middle Aged
Odds Ratio
Polypharmacy
Prospective Studies
Sex Factors
Time Factors
(MeSH): Analgesics
Antidepressants
Chronic Pain
Drug Utilization
Opioids
Journal
Pain medicine (Malden, Mass.)
ISSN: 1526-4637
Titre abrégé: Pain Med
Pays: England
ID NLM: 100894201
Informations de publication
Date de publication:
01 12 2019
01 12 2019
Historique:
pubmed:
13
3
2019
medline:
15
9
2020
entrez:
13
3
2019
Statut:
ppublish
Résumé
Although depression and chronic pain often coexist, few studies have examined antidepressant use among people with pain. This study examines the prevalence and characteristics associated with antidepressant use among people prescribed opioids for chronic noncancer pain (CNCP). Baseline data from a prospective cohort study. Australian community. A total of 1166 people prescribed opioids for CNCP. Baseline data collection consisted of a self-completed seven-day medication diary and telephone interview to collect information on sociodemographic characteristics and mental/physical health using validated questionnaires. Logistic regression was used to examine characteristics associated with antidepressant use, reporting adjusted odds ratios (AORs) and 95% confidence intervals (CIs). Of the 1166 participants, 668 (57.3%) were female, and the median (interquartile range) age was 59 (49-68) years. About half the cohort (N = 637, 54.6%) used antidepressants. Of these, 329 (51.7%) reported moderate to severe depression. Amitriptyline was the most commonly used antidepressant (17.3%). Factors independently associated with antidepressant use were being female (AOR = 1.47, 95% CI = 1.13-1.92), more years lived in pain (AOR = 1.01, 95% CI = 1.00-1.02), and use of nonopioid analgesics (AOR = 1.34, 95% CI = 1.01-1.78), benzodiazepines and related drugs (AOR = 1.84, 95% CI = 1.36-2.49), antiepileptics (AOR = 1.86, 95% CI = 1.38-2.51), and antipsychotics (AOR = 2.15, 95% CI = 1.22-3.77). Antidepressant use is common among people with CNCP prescribed opioids. Those using antidepressants were more likely to use other psychotropic medicines concurrently, highlighting that they are a high-risk population requiring comprehensive assessment to optimize outcomes and reduce potential harms from polypharmacy.
Identifiants
pubmed: 30861530
pii: 5376660
doi: 10.1093/pm/pnz009
pmc: PMC7963210
doi:
Substances chimiques
Analgesics, Non-Narcotic
0
Analgesics, Opioid
0
Anticonvulsants
0
Antidepressive Agents
0
Antipsychotic Agents
0
Benzodiazepines
12794-10-4
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2450-2458Subventions
Organisme : NIDA NIH HHS
ID : R01 DA044170
Pays : United States
Informations de copyright
© 2019 American Academy of Pain Medicine. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
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