[Free light chains assay: Indications and methods].

Dosage des chaînes légères libres : indications et méthodes.
Humans Immunoassay / methods Immunoglobulin Light Chains / analysis Multiple Myeloma / blood Paraproteinemias / blood Prognosis Serologic Tests / methods
Chaines légères libres sériques Free light chains Freelite(®) Gammapathie monoclonale Indications Monoclonal gammopathy Pathophysiology Physiopathologie

Journal

La Revue de medecine interne
ISSN: 1768-3122
Titre abrégé: Rev Med Interne
Pays: France
ID NLM: 8101383

Informations de publication

Date de publication:
May 2019
Historique:
received: 24 09 2018
revised: 04 01 2019
accepted: 20 01 2019
pubmed: 14 3 2019
medline: 28 12 2019
entrez: 14 3 2019
Statut: ppublish

Résumé

Serum free light chains (sFLC) assay is an important marker in plasma cell dyscrasia. It is thus recommended for the diagnosis of monoclonal gammopathy, together with serum protein electrophoresis and immunofixation. sFLC assay has also a prognostic value and is a criterion for treatment response and relapse of some monoclonal gammopathies. Three assays are currently available in France, the gold standard being the Freelite

Identifiants

DOI: 10.1016/j.revmed.2019.01.005 PMID: 30862366
pubmed: 30862366
pii: S0248-8663(19)30045-1
doi: 10.1016/j.revmed.2019.01.005
pii:
doi:

Substances chimiques

Immunoglobulin Light Chains 0

Types de publication

Journal Article Review

Langues

fre

Sous-ensembles de citation

IM

Pagination

297-305

Informations de copyright

Copyright © 2019 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier Masson SAS. All rights reserved.

Auteurs

J-P Martellosio (JP)

Service de médecine interne, maladies infectieuses et tropicales, centre hospitalier universitaire de Poitiers, 2, rue de la Milétrie, 86021 Poitiers cedex, France.

X Leleu (X)

Service d'onco-hématologie et de thérapie cellulaire, centre hospitalier universitaire de Poitiers, Poitiers, France.

P Roblot (P)

Service de médecine interne, maladies infectieuses et tropicales, centre hospitalier universitaire de Poitiers, 2, rue de la Milétrie, 86021 Poitiers cedex, France.

M Martin (M)

Service de médecine interne, maladies infectieuses et tropicales, centre hospitalier universitaire de Poitiers, 2, rue de la Milétrie, 86021 Poitiers cedex, France.

M Puyade (M)

Service de médecine interne, maladies infectieuses et tropicales, centre hospitalier universitaire de Poitiers, 2, rue de la Milétrie, 86021 Poitiers cedex, France. Electronic address: mathieu.puyade@chu-poitiers.fr.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › [Free light chains assay: Indications and methods].
questionsmedicales.fr › Techniques d'investigation › Techniques de sonde moléculaire › Dosage immunologique › [Free light chains assay: Indications and methods].
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Sous-unités des immunoglobulines › Chaines légères des immunoglobulines › [Free light chains assay: Indications and methods].
questionsmedicales.fr › Maladies du système immunitaire › Syndromes immunoprolifératifs › Paraprotéinémies › Myélome multiple › [Free light chains assay: Indications and methods].
questionsmedicales.fr › Maladies du système immunitaire › Syndromes immunoprolifératifs › Paraprotéinémies › [Free light chains assay: Indications and methods].
questionsmedicales.fr › Diagnostic › Pronostic › [Free light chains assay: Indications and methods].
questionsmedicales.fr › Techniques d'investigation › Techniques immunologiques › Tests immunologiques › Tests sérologiques › [Free light chains assay: Indications and methods].