Dynamic molecular changes during the first week of human life follow a robust developmental trajectory.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
12 03 2019
12 03 2019
Historique:
received:
18
02
2018
accepted:
24
01
2019
entrez:
14
3
2019
pubmed:
14
3
2019
medline:
10
4
2019
Statut:
epublish
Résumé
Systems biology can unravel complex biology but has not been extensively applied to human newborns, a group highly vulnerable to a wide range of diseases. We optimized methods to extract transcriptomic, proteomic, metabolomic, cytokine/chemokine, and single cell immune phenotyping data from <1 ml of blood, a volume readily obtained from newborns. Indexing to baseline and applying innovative integrative computational methods reveals dramatic changes along a remarkably stable developmental trajectory over the first week of life. This is most evident in changes of interferon and complement pathways, as well as neutrophil-associated signaling. Validated across two independent cohorts of newborns from West Africa and Australasia, a robust and common trajectory emerges, suggesting a purposeful rather than random developmental path. Systems biology and innovative data integration can provide fresh insights into the molecular ontogeny of the first week of life, a dynamic developmental phase that is key for health and disease.
Identifiants
pubmed: 30862783
doi: 10.1038/s41467-019-08794-x
pii: 10.1038/s41467-019-08794-x
pmc: PMC6414553
doi:
Substances chimiques
Chemokines
0
Cytokines
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Validation Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
1092Subventions
Organisme : NIAID NIH HHS
ID : HHSN272201400052C
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI124284
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI118608
Pays : United States
Investigateurs
Diana Vo
(D)
Ken Kraft
(K)
Kerry McEnaney
(K)
Sofia Vignolo
(S)
Arnaud Marchant
(A)
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