Bile Acid Homeostasis in a Cholesterol 7α-Hydroxylase and Sterol 27-Hydroxylase Double Knockout Mouse Model.
Journal
Hepatology (Baltimore, Md.)
ISSN: 1527-3350
Titre abrégé: Hepatology
Pays: United States
ID NLM: 8302946
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
02
10
2018
accepted:
01
03
2019
pubmed:
14
3
2019
medline:
23
6
2020
entrez:
14
3
2019
Statut:
ppublish
Résumé
Bile acids (BAs) are diverse molecules that are synthesized from cholesterol in the liver. The synthesis of BAs has traditionally been shown to occur through two pathways. Cholesterol 7α-hydroxylase (CYP7A1) performs the initial and rate-limiting step in the classical pathway, and sterol 27-hydroxylase (CYP27A1) initiates the hydroxylation of cholesterol in the alternative pathway. While the role of individual BA species as physiological detergents is relatively ubiquitous, their endocrine functions as signaling molecules and roles in disease pathogenesis have been emerging to be BA species-specific. In order to better understand the pharmacologic and toxicologic roles of individual BA species in an in vivo model, we created cholesterol 7α-hydroxylase (Cyp7a1) and sterol 27-hydroxylase (Cyp27a1) double knockout (DKO) mice by cross-breeding single knockout mice (Cyp7a1
Identifiants
pubmed: 30864232
doi: 10.1002/hep.30612
pmc: PMC7893641
mid: NIHMS1558698
doi:
Substances chimiques
Bile Acids and Salts
0
Cholesterol 7-alpha-Hydroxylase
EC 1.14.14.23
Cyp7a1 protein, mouse
EC 1.14.14.23
Cholestanetriol 26-Monooxygenase
EC 1.14.15.15
Cyp27a1 protein, mouse
EC 1.14.15.15
Types de publication
Evaluation Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
389-402Subventions
Organisme : NIEHS NIH HHS
ID : T32 ES007148
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM104037
Pays : United States
Organisme : NIEHS NIH HHS
ID : R21 ES029258
Pays : United States
Organisme : BLRD VA
ID : I01 BX002741
Pays : United States
Organisme : National Institutes of Health and Department of Veterans Affairs
ID : T32ES007148
Pays : International
Organisme : National Institutes of Health and Department of Veterans Affairs
ID : BX002741
Pays : International
Organisme : NIEHS NIH HHS
ID : P30 ES005022
Pays : United States
Informations de copyright
© 2019 by the American Association for the Study of Liver Diseases.
Références
Compr Physiol. 2013 Jul;3(3):1191-212
pubmed: 23897684
Hepatology. 2013 Apr;57(4):1394-406
pubmed: 23299969
Sci Rep. 2018 Jan 19;8(1):1253
pubmed: 29352187
J Biol Chem. 1998 Jun 12;273(24):14805-12
pubmed: 9614081
Hepatology. 2011 Jan;53(1):272-81
pubmed: 20949553
J Natl Cancer Inst. 1974 Oct;53(4):1093-7
pubmed: 4427390
J Endocrinol. 2016 Mar;228(3):R85-96
pubmed: 26733603
Mol Aspects Med. 2017 Aug;56:34-44
pubmed: 28442273
J Lipid Res. 1998 Sep;39(9):1833-43
pubmed: 9741696
J Biol Chem. 2003 Jun 20;278(25):22980-8
pubmed: 12686551
J Biol Chem. 2000 Dec 15;275(50):39685-92
pubmed: 11001949
Hepatology. 2018 Nov;68(5):1961-1976
pubmed: 29672888
J Lipid Res. 2010 Nov;51(11):3230-42
pubmed: 20671298
Curr Opin Lipidol. 2007 Jun;18(3):289-97
pubmed: 17495603
J Clin Invest. 1994 Mar;93(3):1326-31
pubmed: 8132774
J Biol Chem. 1994 Jan 14;269(2):1340-7
pubmed: 8288599
Nat Rev Gastroenterol Hepatol. 2014 Jan;11(1):55-67
pubmed: 23982684
Annu Rev Biochem. 2003;72:137-74
pubmed: 12543708
Cell Metab. 2013 Feb 5;17(2):225-35
pubmed: 23395169
J Intern Med. 1995 Apr;237(4):395-402
pubmed: 7714463
Pharmacol Rev. 2014 Oct;66(4):948-83
pubmed: 25073467
Anal Chem. 2015 Jan 20;87(2):1127-36
pubmed: 25496250
J Lipid Res. 2001 Oct;42(10):1594-603
pubmed: 11590215
Int Arch Allergy Immunol. 2014;165(1):1-8
pubmed: 25277277
Curr Opin Gastroenterol. 2014 May;30(3):332-8
pubmed: 24625896
J Biol Chem. 2005 Feb 25;280(8):6960-8
pubmed: 15563450
Proc Natl Acad Sci U S A. 1994 Jan 4;91(1):133-7
pubmed: 8278353
Arch Intern Med. 1999 Dec 13-27;159(22):2647-58
pubmed: 10597755
J Biol Chem. 2004 Mar 5;279(10):8856-61
pubmed: 14684751
J Lipid Res. 2016 Dec;57(12):2130-2137
pubmed: 27638959
Hepatology. 2009 May;49(5):1403-18
pubmed: 19296471
Sci Rep. 2012;2:430
pubmed: 22666533