Impaired ABCA1/ABCG1-mediated lipid efflux in the mouse retinal pigment epithelium (RPE) leads to retinal degeneration.

ATP Binding Cassette Transporter 1 / deficiency ATP Binding Cassette Transporter, Subfamily G, Member 1 / deficiency Animals Cell Line Disease Models, Animal Humans Inflammation / pathology Lipid Metabolism Mice Photoreceptor Cells / pathology Retinal Degeneration / physiopathology Retinal Pigment Epithelium / physiopathology

ABCA1 ABCG1 age-related macular degeneration human human biology lipid efflux medicine mouse neuroscience retinal degeneration retinal pigment epithelium

Journal

eLife

ISSN: 2050-084X

Titre abrégé: Elife

Pays: England

ID NLM: 101579614

Informations de publication

Date de publication:
13 03 2019

Historique:

received: 11 01 2019

accepted: 12 03 2019

pubmed: 14 3 2019

medline: 21 3 2020

entrez: 14 3 2019

Statut: epublish

Résumé

Age-related macular degeneration (AMD) is a progressive disease of the retinal pigment epithelium (RPE) and the retina leading to loss of central vision. Polymorphisms in genes involved in lipid metabolism, including the ATP-binding cassette transporter A1 (

Identifiants

DOI: 10.7554/eLife.45100 PMID: 30864945 PMC: PMC6435327

pubmed: 30864945

doi: 10.7554/eLife.45100

pii: 45100

pmc: PMC6435327

doi:

pii:

Substances chimiques

ABCA1 protein, human 0

ABCA1 protein, mouse 0

ABCG1 protein, human 0

ABCG1 protein, mouse 0

ATP Binding Cassette Transporter 1 0

ATP Binding Cassette Transporter, Subfamily G, Member 1 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

Subventions

Organisme : NEI NIH HHS

ID : P30 EY001583

Pays : United States

Organisme : Roche

ID : RPF 378

Pays : International

Organisme : Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

ID : 31003A_173008

Pays : International

Informations de copyright

Déclaration de conflit d'intérêts

FS, KK, VT, RS, AO, Sv, MS, IM, MB, DK, VP, SB, FB, JD, TH, LR, Ad, Av, CG No competing interests declared, CU Employee of F Hoffmann-La Roche Ltd, JF, CM Previous employee of F Hoffmann-La Roche Ltd

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