Chronological storage age and metabolic age of stored red blood cells: are they the same?
Journal
Transfusion
ISSN: 1537-2995
Titre abrégé: Transfusion
Pays: United States
ID NLM: 0417360
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
15
01
2019
revised:
06
02
2019
accepted:
10
02
2019
pubmed:
14
3
2019
medline:
2
6
2020
entrez:
14
3
2019
Statut:
ppublish
Résumé
Red blood cell (RBC) storage in the blood bank is characterized by the progressive loss of metabolic regulation, a phenomenon that targets energy and antioxidant metabolism; While the progression of the storage lesion is inevitable, the rate at which this phenomenon occurs varies from donor to donor; Red blood cells from some donors at the end of storage are metabolically superior to RBCs from other donors at the beginning of storage, suggesting that the age of blood alone may not be a sufficiently accurate predictor of stored blood quality; and Animal studies and large-scale omics screening in blood donors have helped identify mechanistic contributors to the metabolic heterogeneity of stored blood units.
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1620-1623Subventions
Organisme : NHLBI NIH HHS
ID : HHSN2682011
Pays : United States
Informations de copyright
© 2019 AABB.