Synthesis and Antitumor Activity of a Series of Novel 1-Oxa-4-azaspiro[4,5]deca-6,9-diene-3,8-dione Derivatives.
A549 Cells
Antineoplastic Agents
/ chemical synthesis
Cell Line, Tumor
Cell Proliferation
/ drug effects
Cell Survival
/ drug effects
Drug Design
Drug Screening Assays, Antitumor
HeLa Cells
Humans
Inhibitory Concentration 50
Molecular Structure
Oxazoles
/ chemical synthesis
Structure-Activity Relationship
1-oxa-4-azaspiro[4.5]deca-6,9-diene-3,8-dione
antitumor activity
intramolecular oxidation
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
07 Mar 2019
07 Mar 2019
Historique:
received:
09
02
2019
revised:
24
02
2019
accepted:
26
02
2019
entrez:
15
3
2019
pubmed:
15
3
2019
medline:
27
6
2019
Statut:
epublish
Résumé
A series of novel 1-oxa-4-azaspiro[4.5]deca-6,9-diene-3,8-diones were designed and synthesized by using 4-aminophenol and α-glycolic acid or lactic acid as starting materials in three or four steps. The key step is the metal-catalyzed oxidative cyclization of the amide to 1-oxa-4-azaspiro[4.5]deca-6,9-diene-3,8-diones (
Identifiants
pubmed: 30866506
pii: molecules24050936
doi: 10.3390/molecules24050936
pmc: PMC6429447
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Oxazoles
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIMHD NIH HHS
ID : U54 MD007595
Pays : United States
Organisme : NIMHD NIH HHS
ID : 2G12MD007595
Pays : United States
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