CGRP and migraine from a cardiovascular point of view: what do we expect from blocking CGRP?

Antibodies, Monoclonal / therapeutic use Calcitonin Gene-Related Peptide / antagonists & inhibitors Calcitonin Gene-Related Peptide Receptor Antagonists / therapeutic use Cardiovascular System / physiopathology Humans Migraine Disorders / drug therapy Receptors, Calcitonin Gene-Related Peptide / physiology Sex Factors Vasodilation / physiology
CGRP CGRP antibody Cardiovascular Migraine treatment

Journal

The journal of headache and pain
ISSN: 1129-2377
Titre abrégé: J Headache Pain
Pays: England
ID NLM: 100940562

Informations de publication

Date de publication:
12 Mar 2019
Historique:
received: 11 12 2018
accepted: 26 02 2019
entrez: 15 3 2019
pubmed: 15 3 2019
medline: 26 4 2019
Statut: epublish

Résumé

Calcitonin gene-related peptide (CGRP) is a neuropeptide with a pivotal role in the pathophysiology of migraine. Blockade of CGRP is a new therapeutic target for patients with migraine. CGRP and its receptors are distributed not only in the central and peripheral nervous system but also in the cardiovascular system, both in blood vessels and in the heart. We reviewed the current evidence on the role of CGRP in the cardiovascular system in order to understand the possible short- and long-term effect of CGRP blockade with monoclonal antibodies in migraineurs.In physiological conditions, CGRP has important vasodilating effects and is thought to protect organs from ischemia. Despite the aforementioned cardiovascular implication, preventive treatment with CGRP antibodies has shown no relevant cardiovascular side effects. Results from long-term trials and from real life are now needed.

Identifiants

DOI: 10.1186/s10194-019-0979-y PMID: 30866804 PMC: PMC6734543
pubmed: 30866804
doi: 10.1186/s10194-019-0979-y
pii: 10.1186/s10194-019-0979-y
pmc: PMC6734543
doi:

Substances chimiques

Antibodies, Monoclonal 0
Calcitonin Gene-Related Peptide Receptor Antagonists 0
Receptors, Calcitonin Gene-Related Peptide 0
Calcitonin Gene-Related Peptide JHB2QIZ69Z

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

27

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Auteurs

Valentina Favoni (V)

Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy. valentina.favoni2@unibo.it.
IRCCS Istituto delle Scienze Neurologiche di Bologna, Via Altura, 3 Pad. G, 40139, Bologna, Italy. valentina.favoni2@unibo.it.
ORCID: 0000-0001-5335-2438

Luca Giani (L)

Ricovero Ferdinando Uboldi, Paderno Dugnano, Italy.

Linda Al-Hassany (L)

Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.

Gian Maria Asioli (GM)

Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
IRCCS Istituto delle Scienze Neurologiche di Bologna, Via Altura, 3 Pad. G, 40139, Bologna, Italy.

Calogera Butera (C)

Dipartimento Neurologico e INSPE, IRCCS Ospedale San Raffaele, Milan, Italy.

Irene de Boer (I)

Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands.

Martina Guglielmetti (M)

Department of Clinical and Molecular Medicine, Sapienza University, Rome, Italy.
Regional Referral Headache Center, Sant'Andrea Hospital, Rome, Italy.
Department of Clinical Pathology, University of Sassari, Sassari, Italy.

Chrysoula Koniari (C)

1st Neurology Department, Aeginition Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.

Theodoros Mavridis (T)

1st Neurology Department, Aeginition Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.

Marge Vaikjärv (M)

Faculty of Medicine, University of Tartu, Tartu, Estonia.

Iris Verhagen (I)

Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.
Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands.

Angela Verzina (A)

Neurology Clinic, University of Perugia, Perugia, Italy.
S. Maria della Misericordia Hospital, Perugia, Italy.

Bart Zick (B)

Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.
Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands.

Paolo Martelletti (P)

Department of Clinical and Molecular Medicine, Sapienza University, Rome, Italy.
Regional Referral Headache Center, Sant'Andrea Hospital, Rome, Italy.

Simona Sacco (S)

UOC Neurologia e Stroke Unit, Ospedale SS Filippo e Nicola, Avezzano, Italy.
Department of Applied Clinical Sciences and Biotechnology, University of L'Aquila, L'Aquila, Italy.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps monoclonaux › CGRP and migraine from a cardiovascular point...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Neuropeptides › Peptide relié au gène de la calcitonine › CGRP and migraine from a cardiovascular point...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Analgésiques › Antagonistes du récepteur du peptide relié au gène de la calcitonine › CGRP and migraine from a cardiovascular point...
questionsmedicales.fr › Système cardiovasculaire › CGRP and migraine from a cardiovascular point...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › CGRP and migraine from a cardiovascular point...
questionsmedicales.fr › Maladies du système nerveux › Maladies du système nerveux central › Encéphalopathies › Céphalées › Céphalées primitives › Migraines › CGRP and migraine from a cardiovascular point...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur aux neuropeptides › Récepteurs du peptide relié au gène de la calcitonine › CGRP and migraine from a cardiovascular point...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Facteurs épidémiologiques › Facteurs sexuels › CGRP and migraine from a cardiovascular point...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Hémodynamique › Vasodilatation › CGRP and migraine from a cardiovascular point...