The Effect of Aerobic Exercise on White Matter Hyperintensity Progression May Vary by Sex.
aerobic training
aging
différences liées au sexe
entraînement aérobie
exercice
exercise
hyperintensité de la matière blanche
microangiopathie
sex differences
small vessel disease
subcortical ischemic vascular cognitive impairment
trouble cognitif vasculaire ischémique sous-cortical
vieillissement
white matter hyperintensities
Journal
Canadian journal on aging = La revue canadienne du vieillissement
ISSN: 1710-1107
Titre abrégé: Can J Aging
Pays: Canada
ID NLM: 8708560
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
pubmed:
15
3
2019
medline:
31
3
2020
entrez:
15
3
2019
Statut:
ppublish
Résumé
ABSTRACTThis study explored the efficacy of aerobic training (AT) in mitigating white matter hyperintensity (WMH) progression and whether these changes are sex dependent. This was an exploratory analysis of a randomized controlled trial assessing the effect of AT on cognition in people with vascular cognitive impairment. Participants were randomized to a 6 month AT or usual care (control [CON]) group. A subset completed magnetic resonance imaging to quantify WMH volume. Using an analysis of covariance model, we found a significant sex × group interaction (p = .03). Over the 6 month study, AT females demonstrated greater WMH progression than CON females (p = .05). Among males, there was no significant between-group difference (p = .31). Within the AT group, males demonstrated significantly less WMH progression than females (p = .01) at 6 months. Therefore, the effects of AT on WMH progression may vary by sex; that is, AT may curtail WMH progression in males but not females.
Identifiants
pubmed: 30867079
pii: S0714980818000582
doi: 10.1017/S0714980818000582
doi:
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM