Lack of Association between Human Papillomavirus Types 6 and 11 Genetic Variants and Cervical Abnormalities: The Ludwig-McGill Cohort Study.
Adolescent
Adult
Carcinoma, Squamous Cell
/ epidemiology
Cohort Studies
DNA, Viral
/ genetics
Female
Follow-Up Studies
Genetic Variation
Human papillomavirus 11
/ genetics
Human papillomavirus 6
/ genetics
Humans
Middle Aged
Papillomavirus Infections
/ epidemiology
Prognosis
Respiratory Tract Infections
/ epidemiology
Uterine Cervical Neoplasms
/ epidemiology
Vaginal Smears
Young Adult
Uterine Cervical Dysplasia
/ epidemiology
Journal
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
ISSN: 1538-7755
Titre abrégé: Cancer Epidemiol Biomarkers Prev
Pays: United States
ID NLM: 9200608
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
23
01
2019
revised:
06
03
2019
accepted:
07
03
2019
pubmed:
15
3
2019
medline:
7
8
2020
entrez:
15
3
2019
Statut:
ppublish
Résumé
Human papillomavirus (HPV) types 6 and 11 are mainly associated with the development of genital warts and recurrent respiratory papillomatosis. We examined intratypic genetic variability of both viral types with the development of cervical cytologic abnormalities in Brazilian women. We used PCR sequencing to characterize variants of HPVs 6 and/or 11 in cervical swabs from women in the Ludwig-McGill Cohort Study. We used a binomial generalized estimating equations (GEE) model with logit link to estimate odds ratios (OR) and 95% confidence intervals (CI) for the associations between HPV 6 and 11 variants and cytologic abnormalities. B1 and B3 HPV6 and A2 HPV11 variants were the most common isolates identified. Compared with HPV6-negative women, the ORs among women harboring HPV6 B1 or B3 variants were 6.3 (95% CI, 2.3-17.0) and 2.3 (95% CI, 0.6-9.7) for atypical cells of undetermined significance (ASCUS)/low squamous intraepithelial lesions (LSIL), respectively, and 1.7 (95% CI, 0.6-5.1) and 1.2 (95% CI, 0.3-4.7) for ASCUS/LSIL/high squamous intraepithelial lesions (HSIL). Respective ORs were 5.0 (95% CI, 1.7-14.6) and 2.8 (95% CI, 1.0-8.1) upon comparing women with HPV11 A2 variants to HPV11-negative women. All associations disappeared when adjusting for coinfections with high-risk HPV types. Our data do not support an association between low-risk HPVs 6 and 11 genetic variability and cervical abnormalities. Risk of cervical cytologic abnormalities is not affected by intratypic polymorphism in HPVs 6 and 11.
Sections du résumé
BACKGROUND
Human papillomavirus (HPV) types 6 and 11 are mainly associated with the development of genital warts and recurrent respiratory papillomatosis. We examined intratypic genetic variability of both viral types with the development of cervical cytologic abnormalities in Brazilian women.
METHODS
We used PCR sequencing to characterize variants of HPVs 6 and/or 11 in cervical swabs from women in the Ludwig-McGill Cohort Study. We used a binomial generalized estimating equations (GEE) model with logit link to estimate odds ratios (OR) and 95% confidence intervals (CI) for the associations between HPV 6 and 11 variants and cytologic abnormalities.
RESULTS
B1 and B3 HPV6 and A2 HPV11 variants were the most common isolates identified. Compared with HPV6-negative women, the ORs among women harboring HPV6 B1 or B3 variants were 6.3 (95% CI, 2.3-17.0) and 2.3 (95% CI, 0.6-9.7) for atypical cells of undetermined significance (ASCUS)/low squamous intraepithelial lesions (LSIL), respectively, and 1.7 (95% CI, 0.6-5.1) and 1.2 (95% CI, 0.3-4.7) for ASCUS/LSIL/high squamous intraepithelial lesions (HSIL). Respective ORs were 5.0 (95% CI, 1.7-14.6) and 2.8 (95% CI, 1.0-8.1) upon comparing women with HPV11 A2 variants to HPV11-negative women. All associations disappeared when adjusting for coinfections with high-risk HPV types.
CONCLUSIONS
Our data do not support an association between low-risk HPVs 6 and 11 genetic variability and cervical abnormalities.
IMPACT
Risk of cervical cytologic abnormalities is not affected by intratypic polymorphism in HPVs 6 and 11.
Identifiants
pubmed: 30867221
pii: 1055-9965.EPI-19-0114
doi: 10.1158/1055-9965.EPI-19-0114
pmc: PMC6548638
mid: NIHMS1523925
doi:
Substances chimiques
DNA, Viral
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1086-1088Subventions
Organisme : NCI NIH HHS
ID : R01 CA070269
Pays : United States
Organisme : CIHR
ID : MA-13647
Pays : Canada
Organisme : CIHR
ID : MOP-49396
Pays : Canada
Organisme : CIHR
ID : CRN-83320
Pays : Canada
Informations de copyright
©2019 American Association for Cancer Research.
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