Preclinical development of an oral anti-


Journal

Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086

Informations de publication

Date de publication:
13 03 2019
Historique:
received: 17 05 2018
accepted: 19 10 2018
entrez: 15 3 2019
pubmed: 15 3 2019
medline: 23 2 2020
Statut: ppublish

Résumé

There is an urgent global need for a safe macrofilaricide drug to accelerate elimination of the neglected tropical diseases onchocerciasis and lymphatic filariasis. From an anti-infective compound library, the macrolide veterinary antibiotic, tylosin A, was identified as a hit against

Identifiants

pubmed: 30867321
pii: 11/483/eaau2086
doi: 10.1126/scitranslmed.aau2086
pii:
doi:

Substances chimiques

Macrolides 0
Tylosin YEF4JXN031

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Medical Research Council
ID : MC_PC_16052
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/L018756/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R025401/1
Pays : United Kingdom
Organisme : National Centre for the Replacement, Refinement and Reduction of Animals in Research
ID : NC/M00175X/1
Pays : United Kingdom

Informations de copyright

Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).

Auteurs

Mark J Taylor (MJ)

Centre for Drugs and Diagnostics, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK.

Thomas W von Geldern (TW)

Global Pharmaceutical Research and Development, AbbVie, North Chicago, IL, USA.
Franciscan Institute for World Health, Franciscan University, Steubenville, OH, USA.

Louise Ford (L)

Centre for Drugs and Diagnostics, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK.

Marc P Hübner (MP)

Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany.

Kennan Marsh (K)

Global Pharmaceutical Research and Development, AbbVie, North Chicago, IL, USA.

Kelly L Johnston (KL)

Centre for Drugs and Diagnostics, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK.

Hanna T Sjoberg (HT)

Centre for Drugs and Diagnostics, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK.

Sabine Specht (S)

Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany.

Nicolas Pionnier (N)

Centre for Drugs and Diagnostics, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK.

Hayley E Tyrer (HE)

Centre for Drugs and Diagnostics, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK.

Rachel H Clare (RH)

Centre for Drugs and Diagnostics, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK.

Darren A N Cook (DAN)

Centre for Drugs and Diagnostics, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK.

Emma Murphy (E)

Centre for Drugs and Diagnostics, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK.

Andrew Steven (A)

Centre for Drugs and Diagnostics, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK.

John Archer (J)

Centre for Drugs and Diagnostics, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK.

Dominique Bloemker (D)

Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany.

Franziska Lenz (F)

Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany.

Marianne Koschel (M)

Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany.

Alexandra Ehrens (A)

Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany.

Haelly M Metuge (HM)

Research Foundation for Tropical Diseases and the Environment, Buea, Cameroon.
Department of Microbiology and Parasitology, University of Buea, Buea, Cameroon.

Valerinne C Chunda (VC)

Research Foundation for Tropical Diseases and the Environment, Buea, Cameroon.
Department of Microbiology and Parasitology, University of Buea, Buea, Cameroon.

Patrick W Ndongmo Chounna (PW)

Research Foundation for Tropical Diseases and the Environment, Buea, Cameroon.
Department of Microbiology and Parasitology, University of Buea, Buea, Cameroon.

Abdel J Njouendou (AJ)

Research Foundation for Tropical Diseases and the Environment, Buea, Cameroon.
Department of Microbiology and Parasitology, University of Buea, Buea, Cameroon.

Fanny F Fombad (FF)

Research Foundation for Tropical Diseases and the Environment, Buea, Cameroon.
Department of Microbiology and Parasitology, University of Buea, Buea, Cameroon.

Robert Carr (R)

Global Pharmaceutical Research and Development, AbbVie, North Chicago, IL, USA.

Howard E Morton (HE)

Global Pharmaceutical Research and Development, AbbVie, North Chicago, IL, USA.

Ghaith Aljayyoussi (G)

Centre for Drugs and Diagnostics, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK.

Achim Hoerauf (A)

Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany.

Samuel Wanji (S)

Research Foundation for Tropical Diseases and the Environment, Buea, Cameroon.
Department of Microbiology and Parasitology, University of Buea, Buea, Cameroon.

Dale J Kempf (DJ)

Global Pharmaceutical Research and Development, AbbVie, North Chicago, IL, USA.

Joseph D Turner (JD)

Centre for Drugs and Diagnostics, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK.

Stephen A Ward (SA)

Centre for Drugs and Diagnostics, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK. steve.ward@lstmed.ac.uk.

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Classifications MeSH