Radiation exposure of image-guided intrathecal administration of nusinersen to adult patients with spinal muscular atrophy.
Computed tomography
Fluoroscopy
Radiation exposure
Spinal injection
Spinal muscular atrophy
Journal
Neuroradiology
ISSN: 1432-1920
Titre abrégé: Neuroradiology
Pays: Germany
ID NLM: 1302751
Informations de publication
Date de publication:
May 2019
May 2019
Historique:
received:
06
12
2018
accepted:
18
02
2019
pubmed:
15
3
2019
medline:
30
4
2019
entrez:
15
3
2019
Statut:
ppublish
Résumé
To examine diagnostic reference levels (DRL) and achievable doses (AD) of image-guided and size-specific dose estimates (SSDE) and organ and effective doses of CT-guided intrathecal nusinersen administration to adult patients with spinal muscular atrophy (SMA). This study involved a total of 60 image-guided intrathecal nusinersen treatments between August 2017 and June 2018. Patient cohort comprised 14 adult patients with the following SMA types: type 2 (n = 9) and type 3 (n = 5) with a mean age of 33.6 years (age range 25-57 years). DRL, AD, SSDE, organ, and effective doses were assessed with a dose-monitoring program based on the Monte Carlo simulation techniques. DRL and AD for computed tomography are summarised as follows: in terms of CT-dose index (CTDI Radiation exposure of SMA patients measured as DRLs is generally not higher compared with patients without SMA despite severe anatomical hazards. Dose monitoring data may allow clinicians to stratify radiation risk, identify organs at risk, and adopt measures for specific radiation dose reduction.
Identifiants
pubmed: 30868184
doi: 10.1007/s00234-019-02189-x
pii: 10.1007/s00234-019-02189-x
doi:
Substances chimiques
Oligonucleotides
0
nusinersen
5Z9SP3X666
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
565-574Références
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