Biomonitoring of bisphenols A, F, S in human milk and probabilistic risk assessment for breastfed infants.
Bisphenol
Human biomonitoring
Human milk
Infants
Mothers
Risk assessment
Journal
The Science of the total environment
ISSN: 1879-1026
Titre abrégé: Sci Total Environ
Pays: Netherlands
ID NLM: 0330500
Informations de publication
Date de publication:
10 Jun 2019
10 Jun 2019
Historique:
received:
17
12
2018
revised:
02
03
2019
accepted:
02
03
2019
pubmed:
15
3
2019
medline:
19
4
2019
entrez:
15
3
2019
Statut:
ppublish
Résumé
The present study addresses the presence of bisphenols A (BPA) and its analogs bisphenol F (BPF) and S (BPS) in milk of 120 mothers living in Valencia (Spain) and participating in the BETTERMILK project (year 2015). We also studied the factors that could influence the BPA levels and estimated the exposure and the risk for breast fed infants. The frequency of detection of total (conjugated + unconjugated) and unconjugated-BPA were 83% and 77%, with a geometric mean of 0.29 ng/mL and 0.15 ng/mL, respectively. The frequency of detection was much lower for total-BPF (22%) and total-BPS (1.1%). The place of residence of the mother and the use of personal care products showed significant association with BPA concentrations. The estimated daily intake of total-BPA for breastfed infants amounted to a geometric mean of 0.04 μg/kg bw and a 95th percentile of 1.0 μg/kg bw, below the tolerable daily intake of 4 μg/kg bw-day established by EFSA. To our knowledge, this is the largest biomonitoring study of bisphenols in human milk in Europe.
Identifiants
pubmed: 30870748
pii: S0048-9697(19)31002-2
doi: 10.1016/j.scitotenv.2019.03.024
pii:
doi:
Substances chimiques
Benzhydryl Compounds
0
Environmental Pollutants
0
Phenols
0
Sulfones
0
bisphenol F
0
bis(4-hydroxyphenyl)sulfone
80-09-1
bisphenol A
MLT3645I99
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
797-805Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.