Hypoxia Induces Astrocyte-Derived Lipocalin-2 in Ischemic Stroke.
astrocyte
hypoxia
lipocalin-2
neuroinflammation
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
13 Mar 2019
13 Mar 2019
Historique:
received:
21
01
2019
revised:
22
02
2019
accepted:
07
03
2019
entrez:
16
3
2019
pubmed:
16
3
2019
medline:
27
6
2019
Statut:
epublish
Résumé
Ischemic stroke causes rapid hypoxic damage to the core neural tissue which is followed by graded chronological tissue degeneration in the peri-infarct zone. The latter process is mainly triggered by neuroinflammation, activation of inflammasomes, proinflammatory cytokines, and pyroptosis. Besides microglia, astrocytes play an important role in the fine-tuning of the inflammatory network in the brain. Lipocalin-2 (LCN2) is involved in the control of innate immune responses, regulation of excess iron, and reactive oxygen production. In this study, we analyzed LCN2 expression in hypoxic rat brain tissue after ischemic stroke and in astrocyte cell cultures receiving standardized hypoxic treatment. Whereas no LCN2-positive cells were seen in sham animals, the number of LCN2-positive cells (mainly astrocytes) was significantly increased after stroke.
Identifiants
pubmed: 30871254
pii: ijms20061271
doi: 10.3390/ijms20061271
pmc: PMC6471434
pii:
doi:
Substances chimiques
Cytokines
0
Lcn2 protein, rat
0
Lipocalin-2
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : interdisciplinary Center for Clinical Research within the faculty of Medicine at the RWTH Aachen University
ID : IZKF AP1-3
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