SIGMAR1/Sigma-1 receptor ablation impairs autophagosome clearance.
Animals
Apoptosis
/ drug effects
Autophagosomes
/ drug effects
Autophagy
/ drug effects
Carbonyl Cyanide m-Chlorophenyl Hydrazone
/ pharmacology
Cell Line, Tumor
Cells, Cultured
Female
Humans
Lysosomes
/ drug effects
Male
Membrane Fusion
/ drug effects
Mice
Mice, Inbred C57BL
Mice, Knockout
Mitochondria
/ metabolism
Mitophagy
/ drug effects
Neurons
/ drug effects
Reactive Oxygen Species
/ metabolism
Receptors, sigma
/ genetics
Retina
/ drug effects
SNARE Proteins
/ metabolism
Ubiquitin-Protein Ligases
/ genetics
Sigma-1 Receptor
CRISPR knockout and knockdown
Sigma-1 receptor
autophagosome-lysosome fusion
autophagy
mitophagy
Journal
Autophagy
ISSN: 1554-8635
Titre abrégé: Autophagy
Pays: United States
ID NLM: 101265188
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
pubmed:
16
3
2019
medline:
7
7
2020
entrez:
16
3
2019
Statut:
ppublish
Résumé
Autophagosome-lysosome fusion is a common critical step in various forms of macroautophagy/autophagy including mitophagy, the selective degradation of mitochondria. Regulations of this fusion process remain poorly defined. Here we have determined the role of SIGMAR1, a unique endoplasmic reticulum membrane protein. Knockout of
Identifiants
pubmed: 30871407
doi: 10.1080/15548627.2019.1586248
pmc: PMC6693456
doi:
Substances chimiques
Reactive Oxygen Species
0
Receptors, sigma
0
SNARE Proteins
0
Carbonyl Cyanide m-Chlorophenyl Hydrazone
555-60-2
Ubiquitin-Protein Ligases
EC 2.3.2.27
parkin protein
EC 2.3.2.27
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1539-1557Subventions
Organisme : NEI NIH HHS
ID : R01 EY022678
Pays : United States
Organisme : NEI NIH HHS
ID : P30 EY016665
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000427
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY029809
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002373
Pays : United States
Commentaires et corrections
Type : ErratumIn
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