Fructose-1,6-bisphosphatase: From a glucose metabolism enzyme to multifaceted regulator of a cell fate.
FBP2
FBPase
GSK3
Mitochondria
Moonlighting
Muscle aldolase
Nucleus
Journal
Advances in biological regulation
ISSN: 2212-4934
Titre abrégé: Adv Biol Regul
Pays: England
ID NLM: 101572336
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
27
02
2019
revised:
04
03
2019
accepted:
05
03
2019
pubmed:
16
3
2019
medline:
16
4
2020
entrez:
16
3
2019
Statut:
ppublish
Résumé
Fructose-1,6-bisphosphatase (FBPase) is one of the ancient, evolutionarily conserved enzymes of carbohydrate metabolism. It has been described for a first time in 1943, however, for the next half a century mostly kinetic and structural parameters of animal FBPases have been studied. Discovery of ubiquitous expression of the muscle isozyme of FBPase, thus far considered to merely regulate glycogen synthesis from carbohydrate precursors, and its nuclear localisation in several cell types has risen new interest in the protein, resulting in numerous publications revealing complex functions/properties of FBPase. This review summarises the current knowledge of FBPase in animal cells providing evidence that the enzyme merits the name of moonlighting protein.
Identifiants
pubmed: 30871972
pii: S2212-4926(19)30027-2
doi: 10.1016/j.jbior.2019.03.001
pii:
doi:
Substances chimiques
Isoenzymes
0
Glycogen
9005-79-2
Fructose-Bisphosphatase
EC 3.1.3.11
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
41-50Informations de copyright
Copyright © 2019. Published by Elsevier Ltd.